喉咽清颗粒联合磷酸奥司他韦治疗小儿乙型流行性感冒的临床效果  

Clinical effect of Houyanqing Granules combined with Oseltamivir Phosphate in the treatment of influenza B in children

作　　者：吕仁杰 刘靖 孙政 LYU Renjie;LIU Jing;SUN Zheng(Department of Pediatrics,Wuxi Children's Hospital,Jiangsu Province,Wuxi214000,China;Department of Pediatrics Internal Medicine,Dongting Branch,Xishan People's Hospital,Jiangsu Province,Wuxi214000,China)

机构地区：[1]江苏省无锡市儿童医院儿科,江苏无锡214000 [2]江苏省无锡市锡山人民医院东亭分院儿内科,江苏无锡214000

出　　处：《中国当代医药》2024年第34期60-64,共5页China Modern Medicine

摘　　要：目的探讨喉咽清颗粒联合磷酸奥司他韦治疗小儿乙型流行性感冒的临床效果。方法选取2023年5月至2024年5月无锡市儿童医院收治的90例小儿乙型流行性感冒患儿作为研究对象,按照随机数字表法分为对照组与观察组,每组各45例。对照组采用磷酸奥司他韦治疗,观察组在对照组方法的基础上加用喉咽清颗粒。比较两组患儿的临床疗效、中医证候积分、炎症因子、免疫功能,以及不良反应。结果观察组的治疗总有效率高于对照组,差异有统计学意义(P<0.05);两组患儿治疗前的中医证候积分比较,差异无统计学意义(P>0.05);两组患儿治疗后的中医证候积分均低于本组治疗前,且观察组治疗后的中医证候积分均低于对照组,差异有统计学意义(P<0.05);两组患儿治疗前的炎症因子各指标水平比较,差异无统计学意义(P>0.05);两组患儿治疗后的炎症因子各指标水平均低于本组治疗前,且观察组治疗后的炎症因子各指标水平均低于对照组,差异有统计学意义(P<0.05)。两组患儿治疗前的免疫功能各指标水平比较,差异无统计学意义(P>0.05);两组患儿治疗后的CD4^(+)、CD4^(+)/CD8^(+)水平高于本组治疗前,CD8^(+)水平低于本组治疗前,且观察组治疗后的CD4^(+)、CD4^(+)/CD8^(+)水平均高于对照组,CD8^(+)水平低于对照组,差异有统计学意义(P<0.05);两组均未见明显不良反应。结论小儿乙型流行性感冒采用喉咽清颗粒与磷酸奥司他韦联合治疗效果明显,利于改善患儿发热、咽痛、咳嗽等临床症状,增强患儿免疫力,减轻患儿炎性反应,且安全性较高。Objective To explore the clinical effect of Houyanqing Granules combined with Oseltamivir Phosphate in the treatment of influenza B in children.Methods A total of 90 children with influenza B admitted to Wuxi Children's Hospital from May 2023 to May 2024 were selected as research subjects,and they were divided into control group and observation group according to the random number table method,with 45 cases in each group.The control group was treated with Oseltamivir Phosphate,and the observation group was treated with Houyanqing Granules on the basis of the control group.The clinical efficacy,traditional Chinese medicine syndrome score,inflammatory factors,immune function and adverse reactions were compared between the two groups.Results The total effective rate of the observation group was higher than that of the control group,the difference was statistically significant(P<0.05).There were no statistically significant difference in traditional Chinese medicine syndrome scores between the two groups before treatment(P>0.05).The traditional Chinese medicine syndrome scores of the two groups after treatment were lower than those before treatment,and the traditional Chinese medicine syndrome scores of the observation group after treatment were lower than those of the control group,and the differences were statistically significant(P<0.05).There were no significant differences in the levels of inflammatory factors between the two groups before treatment(P>0.05).After treatment,the levels of inflammatory factors in the two groups were lower than those before treatment,and the levels of inflammatory factors in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).There were no statistically significant differences in the levels of immune function indexes between the two groups before treatment(P>0.05).The levels of CD4^(+)and CD4^(+)/CD8^(+)in the two groups after treatment were higher than those before treatment,and the level of CD8^(+)was lower th

关 键 词：小儿乙型流行性感冒 喉咽清颗粒 磷酸奥司他韦 中医证候积分 炎症因子 

分 类 号：R725.6[医药卫生—儿科]