铁死亡与其在肺部疾病发生发展作用中的研究现状  

Role of ferroptosis in the occurrence and progression of pulmonary diseases

作　　者：陈序 罗福娣 黄杰良 赖成泽 施莹莹 李世昌 苏鸿天 陶玉坚 郭莲仙 孙艳芹 CHEN Xu;LOU Fudi;HUANG Jieliang;LAI Chengze;SHI Yingying;LI Shichang;SU Hongtian;TAO Yujian;GUO Lianxian;SUN Yanqin(Dongguan Key Laboratory of Environmental Medicine,School of Public Health,Guangdong Medical University,Dongguan 523808,China;Respiratory and Critical Care Medicine Department,Affiliated Hospital of Yangzhou University,Yangzhou 225000,China;Department of Pathology,Guangdong Medical University,Dongguan 523808,China)

机构地区：[1]广东医科大学公共卫生学院,广东东莞523808 [2]扬州大学附属医院呼吸与危重症医学科,江苏扬州225000 [3]广东医科大学病理学系,广东东莞523808

出　　处：《广东医科大学学报》2024年第5期492-500,共9页Journal of Guangdong Medical University

基　　金：广东省基础与应用基础研究基金(2021B1515140067,2022A1515012190)。

摘　　要：非小细胞肺癌、慢性阻塞性肺疾病、肺炎、急性肺损伤、哮喘和肺纤维化等呼吸系统疾病是全球主要的健康问题。铁死亡,一种依赖于细胞内Fe2+积累和脂质过氧化的新型程序性细胞死亡的方式,为这些肺部疾病的治疗提供了新的靶点。研究显示,铁螯合剂、抗氧化剂能通过调节铁代谢和脂质过氧化从而影响细胞命运。研究铁死亡以及开发新的干预策略,如针对铁死亡途径的小分子抑制剂,可能对改善肺部疾病的治疗效果有显著影响。该综述探讨了铁死亡在肺部疾病中的作用及其治疗潜力,旨在为肺部疾病的治疗提供新的思路和见解。Non-small cell lung cancer,chronic obstructive pulmonary disease(COPD),pneumonia,acute lung injury,asthma,and pulmonary fibrosis are major global health issues.Ferroptosis,a novel form of programmed cell death dependent on intracellular Fe2+accumulation and lipid peroxidation,has provided new therapeutic targets for these pulmonary diseases.Research indicates that iron chelators and antioxidants can influence cell fate by modulating iron metabolism and lipid peroxidation.Investigating ferroptosis to develop new intervention strategies,such as small molecule inhibitors targeting the ferroptosis pathway,could significantly improve treatment outcomes for pulmonary diseases.This review summarized the role of ferroptosis in lung diseases and its therapeutic potential,aiming to offer new insights and perspectives for the treatment of pulmonary disorders.

关 键 词：铁死亡 铁超载 脂质代谢紊乱 肺部疾病 氧化应激 线粒体损伤 

分 类 号：R56[医药卫生—呼吸系统]