多胺代谢在精神分裂症中的研究进展  

Progress of polyamine metabolism in pathogenesis of schizophrenia

作　　者：温世怡 邱贤秀 曾今诚 WEN Shiyi;QIU Xianxiu;ZENG Jincheng(Dongguan Key Laboratory of Medical Bioactive Molecular Developmental and Translational Research,Guangdong Provincial Key Laboratory of Medical Immunology and Molecular Diagnostics,Institute of Laboratory Medicine,Guangdong Medical University,Dongguan 523808,China;Department of Clinical Laboratory,Maoming Third People’s Hospital,Maoming 525200,China)

机构地区：[1]广东医科大学医学技术学院//东莞市医学活性分子开发与转化重点实验室//广东省医学免疫与分子诊断重点实验室,广东东莞523808 [2]茂名市第三人民医院检验科,广东茂名525200

出　　处：《广东医科大学学报》2024年第5期507-510,517,共5页Journal of Guangdong Medical University

基　　金：国家自然科学基金项目(32000864);东莞市社会发展科技项目(20221800905612)。

摘　　要：多胺代谢在中枢神经系统和其他器官的多种细胞功能中发挥重要作用。越来越多研究表明多胺代谢与精神分裂症(schizophrenia,SCZ)的病理变化密切相关。在SCZ患者和该疾病的动物模型中,已经证实了多胺以及其前体、衍生物、代谢酶和相关基因表达的变化。该文就多胺代谢在SCZ中的研究进展进行综述,以期为靶向多胺代谢的SCZ治疗提供新的思路。Polyamine metabolism plays an important role in a variety of cellular functions in the central nervous system and other organs.More and more studies have shown that polyamine metabolism is closely related to the pathological changes of schizophrenia.In patients with schizophrenia and in animal models of the disease,it has been confirmed that there are changes in the polyamines,their precursors,derivatives,metabolic enzymes and expression of related genes.This article reviews the research progress of polyamine metabolism in schizophrenia,in order to provide a new idea for schizophrenia treatment targeting polyamine metabolism.

关 键 词：多胺代谢 精神分裂症 

分 类 号：R392.9[医药卫生—免疫学]