磷酸转移酶系统影响细菌生物膜形成的研究进展  

Advances in the study of the bacterial phosphotransferase system affecting bacterial biofilms by regulating sugar metabolism

作　　者：白纯清 李雪萌 郭震 刘军 BAI Chunqing;LI Xuemeng;GUO Zhen;LIU Jun(Laboratory of Pathogen Biology,Guangdong Medical University,Zhanjiang 524023,China;Zhanjiang Key Laboratory of Human Microecologyand Clinical Translation Research,Zhanjiang 524023,China)

机构地区：[1]广东医科大学病原生物学实验室,广东湛江524023 [2]湛江市人体微生态研究与临床转化重点实验室,广东湛江524023

出　　处：《广东医科大学学报》2024年第5期511-517,共7页Journal of Guangdong Medical University

基　　金：国家自然科学基金(82301752);广东省自然科学基金(2018A0303070018);广东省医学科学技术研究基金项目(A2021207);广东省普通高校特色创新项目(2020KJSCX041)。

摘　　要：细菌生物膜(BF)是细菌在物体表面形成的一种复杂三维结构,具有高度耐药性和环境适应性。BF的形成是细菌适应环境和导致持续感染的重要方式,其存在严重威胁人类健康。细菌磷酸转移酶系统(PTS)作为细菌糖类摄取和代谢糖类的关键系统,在细菌代谢和信号传导中发挥至关重要的作用,其通过独特的磷酸化级联反应,从而精确调控糖类的运输和代谢,进而影响细菌的生理状态和行为模式。该文就PTS关键组分在不同细菌中对其BF影响的研究进展作一综述。Bacterial biofilm(BF)is a complex three-dimensional structure formed by bacteria on the surface of an object that is highly resistant to drugs and environmentally adapted.The formation of BF is an important way for bacteria to adapt to the environment and lead to persistent infections,and its presence poses a serious threat to human health.The bacterial phosphotransferase system(PTS),a key system for bacterial sugar uptake and metabolism of sugars,plays a crucial role in bacterial metabolism and signaling through a unique phosphorylation cascade reaction PTS precisely regulating sugar transport and metabolism,which in turn affects bacterial physiological states and behavioral patterns.This article provides a review of the progress of research on the effects of key components of PTS on its BF in different bacteria.

关 键 词：磷酸转移酶系统 细菌 生物膜 糖代谢 

分 类 号：Q93[生物学—微生物学]