基于加权TOPSIS法的伊立替康用药合理性评价  

Evaluation on rational application of irinotecan based on weighted TOPSIS method

作　　者：王旭东 汪龙[3] 黄佩文 张莉[4] 葛磊 邱季 WANG Xu-dong;WANG Long;HUANG Pei-wen;ZHANG Li;CE Lei;QIU Ji(Department of Pharmacy,Binhu Hospital of Hefei,Hefei ANHUI 230000,China;Department of Oncology,Binhu Hospital of Hefei,Hefei ANHUI 230000,China;Department of Pharmacy,the Third People's Hospital of Bengbu,Bengbu ANHUI 233099,China;Department of Pharmacy,the Second Affiliated Hospital of Bengbu Medical College,Bengbu ANHUI 233040,China)

机构地区：[1]合肥市滨湖医院药学部,安徽合肥230000 [2]合肥市滨湖医院肿瘤内科,安徽合肥230000 [3]蚌埠市第三人民医院药学部,安徽蚌埠233099 [4]蚌埠医学院第二附属医院完药学部,安徽蚌埠233040

出　　处：《中国新药与临床杂志》2024年第11期845-851,共7页Chinese Journal of New Drugs and Clinical Remedies

基　　金：安徽省卫生健康科研项目(AHWJ2022b104)。

摘　　要：目的基于加权TOPSIS法评价伊立替康的用药合理性。方法以国内药品说明书为基础,结合相关指南和文献,以“适应证、禁忌证、用法用量、溶媒选择、基线检查、预处理、给药顺序、血常规监测、剂量调整、不良反应监测”为评价指标,采用加权TOPSIS法建立伊立替康用药合理性评价标准,对合肥市滨湖医院2022年1月1日至2023年5月31日使用伊立替康的住院患者的归档病历进行伊立替康用药合理性评价。结果10项评价指标中,相对权重系数最高的为适应证(0.1331),最低的为预处理(0.0849)。共纳入97份病历,其中相对接近度(C_(i))≥0.8的有10份(10%),评价为合理用药;0.6≤C_(i)<0.8的有79份(81%),评价为基本合理用药;C_(i)<0.6的有8份(8%),评价为不合理用药。结论加权TOPSIS法可用于伊立替康用药合理性评价,本院伊立替康的使用基本合理,但仍存在基线检查、血常规监测和适应证不合理等问题。AIM To evaluate the rationality of irinotecan application based on weighted TOPSIS method.METHODS Based on the drug label of irinotecan,combined with relevant guidelines and literatures,weighted TOPSIS method was used to establish the evaluation criteria for the rationality of irinotecan clinical application,with“indications,contraindications,application and dosage,solvent selection,baseline examination,pretreatment,administration sequence,blood routine monitoring,dosage adjustment and ADR monitoring”as evaluation indicators.The archived medical records of inpatients who had used irinotecan in Binhu Hospital of Hefei from January 1,2022 to May 31,2023 were evaluated for the rationary of irinotecan administration.RESULTS Among the 10 evaluation indicators,the highest relative weighted index was indication(0.1331),while the lowest was pretreatment(0.0849).Among the included 97 cases,10 cases(10%)had relative proximity(C_(i))≥0.8,with the evaluation result as rational drug application;79 cases(81%)had 0.6≤C_(i)<0.8,with the evaluation result as basic rational drug application;8 cases(8%)had 0.4≤C_(i)<0.6,with the evaluation result as irrational drug application.CONCLUSION The weighted TOPSIS method can be used to evaluate the rational usage of irinotecan.In our hospital,the use of irinotecan is basically reasonable,however,there are still some problems about baseline examination,blood routine monitoring and unreasonable indications.

关 键 词：加权TOPSIS法 伊立替康 药物利用评审 合理用药 

分 类 号：R979.1[医药卫生—药品]