糖尿病肾病低蛋白饮食治疗效果评估分析  

Evaluation and Analysis of The Therapeutic Effect of Low Protein Diet on Diabetes Nephropathy

作　　者：胡招英 HU Zhaoying(Department of Nursing,General Hospital of Shaxian District,Sanming 365500,China)

机构地区：[1]三明市沙县区总医院护理部,三明365500

出　　处：《中国医药指南》2024年第35期111-113,共3页Guide of China Medicine

摘　　要：目的分析糖尿病肾病患者应用低蛋白饮食治疗的效果。方法选取三明市沙县区总医院2020年1月至2023年10月接受治疗的70例糖尿病肾病患者,采用随机数字表法分为对照组(35例,常规药物治疗)与观察组(35例,常规药物联合低蛋白饮食治疗)。对比两组肾功能指标[血肌酐(Scr)、尿素氮(BUN)和24 h尿蛋白(24 h UTP)]、生化检验指标(空腹血糖、糖化血红蛋白及甘油三酯)、氧化产物及抗氧化指标[血清丙二醛(MDA)、晚期氧化蛋白产物(AOPP)、过氧化氢酶(CAT)、超氧化物歧化酶(SOD)和总抗氧化能力(T-AOC)]。结果治疗前,两组肾功能指标Scr、BUN、24 h UTP水平无差异(P>0.05);治疗后,观察组Scr、BUN、24 h UTP低于对照组(P<0.05)。治疗前,两组空腹血糖、糖化血红蛋白、甘油三酯无差异(P>0.05);治疗后,观察组空腹血糖、糖化血红蛋白、甘油三酯水平均低于对照组(P<0.05)。治疗前,两组MDA、AOPP、CAT、SOD、T-AOC水平对比无差异(P>0.05);治疗后,观察组MDA、AOPP水平低于对照组,CAT、SOD、T-AOC水平高于对照组(P<0.05)。结论将低蛋白饮食治疗方式应用于糖尿病肾病治疗中效果显著,能够有效调整患者的营养摄入,调节氧化-抗氧化平衡,切实改善肾功能与血糖、血脂水平,延缓疾病恶化进程。Objective To analyze the effect of low-protein diet therapy in patients with diabetic nephropathy.Methods A total of 70 patients with diabetic nephropathy treated at the General Hospital of Shaxian District,Sanming,from January 2020 to October 2023,were selected and divided into two groups using the random number table method,the control group(35 cases,conventional drug treatment)and the observation group(35 cases,conventional drug treatment combined with low-protein diet therapy).Renal function indicators(ScrBUN,and 24 h UTP),biochemical test indicators(fasting blood glucose,glycated hemoglobin,and triglycerides),oxidative products and antioxidant indicators(MDA,AOPP,CAT,SOD,and T-AOC)were compared between the two groups.Results Before treatment,there was no difference in Scr,BUN,and 24 h UTP levels between the two groups(P>0.05).After treatment,the levels of Scr,BUN,and 24 h UTP in the observation group were lower than those in the control group(P<0.05).Before treatment,there was no difference in fasting blood glucose,glycated hemoglobin,and triglyceride levels between the two groups(P>0.05).After treatment,the levels of fasting blood glucose,glycated hemoglobin,and triglycerides in the observation group were lower than those in the control group(P<0.05).Before treatment,there was no difference in MDA,AOPP,CAT,SOD,and T-AOC levels between the two groups(P>0.05).After treatment,the levels of MDA and AOPP in the observation group were lower than those in the control group,while the levels of CAT,SOD,and T-AOC were higher than those in the control group(P<0.05).Conclusions The application of low-protein diet therapy in the treatment of diabetic nephropathy is significantly effective,which can effectively adjust the patient’s nutritional intake,regulate the balance of oxidation and antioxidation,and truly improve renal function as well as blood sugar and blood lipid levels,delaying the progression of the disease.

关 键 词：糖尿病肾病 低蛋白饮食 治疗效果 氧化-抗氧化平衡 

分 类 号：R587.2[医药卫生—内分泌]