急性脑梗死与血浆瘦素、白细胞介素-1、白细胞介素-6、超敏C反应蛋白、肿瘤坏死因子-α及网膜素的相关性研究  

Correlation between acute cerebral infarction and plasma leptin,IL-1,IL-6,hs-CRP,TNF-αand omentin

作　　者：孔祥辉 解春雪 陈玉婷 李明 KONG Xianghui;XIE Chunxue;CHEN Yuting;LI Ming

机构地区：[1]荆门市中心医院,湖北荆门448000

出　　处：《中医临床研究》2024年第24期19-22,共4页Clinical Journal Of Chinese Medicine

基　　金：荆门市科技计划项目(2019YFYB032)。

摘　　要：目的:观察急性脑梗死与血浆瘦素、白细胞介素(Interleukin,IL)-1、IL-6、超敏C反应蛋白(Hypersensitive C-reactive Protein,hs-CRP)、肿瘤坏死因子(Tumor Necrosis Factor,TNF)-α及网膜素的相关性。方法:选取于2018年10月―2020年10月接收的中老年急性脑梗死患者50例作为试验组,其中25例血管内膜增厚患者作为B组、25例动脉粥样斑块形成患者作为C组,另选取健康人50例作为对照组(A组),三组均进行血糖、血脂、血尿酸、血清瘦素、血清网膜素、IL-1、IL-6、hs-CRP、TNF-α的检测,对比组间及组内检测结果。结果:试验组血糖、血脂、血尿酸、血清瘦素、IL-1、IL-6、hs-CRP、TNF-α均高于对照组,且血清网膜素低于对照组,差异有统计学意义(P<0.05);C组血糖、血脂、血尿酸、血清瘦素、IL-1、IL-6、hs-CRP、TNF-α均高于B组,且血清网膜素低于B组,差异有统计学意义(P<0.05)。结论:血糖、血脂、血尿酸、血清瘦素、IL-1、IL-6、hs-CRP、TNF-α的含量与中老年急性脑梗死的严重程度呈正相关,血清网膜素与中老年急性脑梗死的严重程度呈负相关,此方法诊断效果显著,安全性好,应多加推广应用。Objective:To observe the correlation between acute cerebral infarction and plasma leptin,IL-1,IL-6,hs-CRP,TNF-αand omentin.Methods:A total of 50 middle-aged and elderly patients with acute cerebral infarction who were admitted from October 2018 to October 2020 were selected as the experimental group.Among them,25 patients with intima thickening were selected as group B,25 patients with atheromatous plaque formation were selected as group C,and 50 healthy people were selected as the control group(group A).Blood glucose,blood lipid,serum uric acid,serum leptin,serum omentinin,IL-1,IL-6,hs-CRP,TNF-αwere detected in the three groups,and the detection results between groups and within group were compared.Results:Blood glucose,blood lipid,serum uric acid,serum leptin,IL-1,IL-6,hs-CRP,and TNF-αin the experimental group were lower than those in the control group,serum retinin was higher than that in the control group,and the differences were statistically significant(P<0.05).The blood glucose,blood lipid,serum uric acid,serum leptin,IL-1,IL-6,hs-CRP and TNF-αin group C were lower than those in group B,and the serum retinin in group C was higher than that in group B,the differences were statistically significant(P<0.05).Conclusion:The contents of blood glucose,blood lipid,uric acid,leptin,IL-1,IL-6,hs-CRP,TNF-αare positively correlated with the severity of acute cerebral infarction in middle-aged and elderly patients.Serum retinin is negatively correlated with the severity of acute cerebral infarction in middle-aged and elderly patients.The diagnostic effect of this method is significant,and its safety is good.

关 键 词：急性脑梗死 中医证候 血浆瘦素 网膜素 

分 类 号：R25[医药卫生—中医内科学]