蒙药蓝刺头防治绝经后骨质疏松的研究进展  

A review on Mongolian medicine Lancitou in the prevention and treatment of postmenopausal osteoporosis

作　　者：凌小松 刘岩[2] LING Xiaosong

机构地区：[1]内蒙古医科大学研究生院,内蒙古呼和浩特010110 [2]内蒙古医科大学附属医院,内蒙古呼和浩特010050

出　　处：《中医临床研究》2024年第31期117-121,共5页Clinical Journal Of Chinese Medicine

基　　金：内蒙古自治区蒙医药协同创新中心科学研究项目(MYYXTPY202310);国家中医药管理局人事教育司项目;常虹全国名老中医药专家传承工作室;内蒙古医科大学面上项目(YKD2022MS044);内蒙古自治区卫生健康委医疗卫生科技计划项目(202201281);内蒙古医科大学“致远”人才计划“善学”人才项目(ZY0202021);内蒙古自然科学基金项目(2019MS08023、2014MS0839、2010MS1151)。

摘　　要：绝经后骨质疏松症是女性绝经后卵巢内分泌功能失调,雌激素水平下降导致的一种代谢性疾病。大量研究证实,绝经后妇女应用雌激素可以有效预防骨量丢失,但长期使用会对人体产生诸多不利影响。目前,药物联合疗法为治疗此病的新趋势,从中医学中寻找一种雌激素替代药物对预防和治疗绝经后骨质疏松症具有重要意义。将传统中医学与民族医学相结合,对防治绝经后骨质疏松症有显著疗效。蓝刺头是蒙医骨伤科常用药,多分布于我国东北、内蒙古等地区,是蒙医自采自用的野生草药之一。蓝刺头具有清热解毒、疗伤接骨等功效,常被用于防治骨质疏松类疾病。蓝刺头的雌激素样作用通过调节骨吸收-形成偶联提高骨密度,进而防止骨量的快速丢失。近年来对蓝刺头的化学、药理研究逐渐增多,其抗骨质疏松作用也多次得到证实。但蓝刺头防治绝经后骨质疏松症的研究大多侧重于单靶点研究,还需进一步探索其促进骨折愈合的机制。本研究对蓝刺头抗绝经后骨质疏松症作用进行多方面归纳总结,以期为临床提供参考。Postmenopausal osteoporosis is a metabolic disease caused by the decline of ovarian endocrine dysfunction and estrogen level in postmenopausal women.A large number of studies have confirmed that estrogen can effectively prevent bone loss in postmenopausal women,but long-term use of estrogen treatment will have many adverse effects on the human body.At present,the new trend in the treatment of postmenopausal osteoporosis is the combination of medicines.Finding an alternative to estrogen in traditional Chinese medicine plays an important role in the prevention and treatment of postmenopausal osteoporosis.The combination of traditional Chinese medicine and ethnic medicine has a significant effect on the prevention and treatment of postmenopausal osteoporosis.As a common medicine in the orthopedics and traumatology department of Mongolian medicine,Lancitou(蓝刺头)is distributed in northeast China,Inner Mongolia and other places.It is one of the wild herbs collected by Mongolian medicine for self-use,has the effects of bone healing,pain relief and heat clearing,and is often used in the treatment of osteoporosis,fractures,sores and so on.The estrogen-like effect of the Lancitou increases bone density by regulating bone resorption-formation coupling,thereby preventing rapid loss of bone mass.In recent years,the chemical and pharmacological research of Lancitou has gradually increased,and its anti-osteoporosis effect has been confirmed for many times.However,most of its research on the prevention and treatment of postmenopausal osteoporosis focuses on single-target research,the mechanism of Lancitou in promoting fracture healing still needs to be further explored.This article summarizes the anti-postmenopausal osteoporosis effect of Lancitou from various aspects,and provide scientific guidance for the rational application of Lancitou in clinic.

关 键 词：蒙药 蓝刺头 绝经后骨质疏松 雌激素 民族医学 

分 类 号：R322.71[医药卫生—人体解剖和组织胚胎学]