血清脂联素和网膜素-1与冠心病患者发生冠状动脉钙化及其严重程度的关系  

Association of Serum Adiponectin and Omentin-1 with Coronary Artery Calcification and Its Severity in Patients with Coronary Heart Disease

作　　者：任园园 程功[1] 赵沱 REN Yuanyuan;CHENG Gong;ZHAO Tuo(Department of Cardiovascular Medicine,Honghui Hospital,Xi'an Jiaotong University,Xi'an 710068,China;Department of Cardiovascular Medicine,Chang'an Hospital,Xi'an 710068,China)

机构地区：[1]西安交通大学附属红会医院心血管内科,陕西省西安市710068 [2]长安医院心血管内科,陕西省西安市710068

出　　处：《实用心脑肺血管病杂志》2025年第1期39-43,共5页Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease

基　　金：陕西省自然科学基础研究计划项目(2022JQ-891);陕西省人民医院科技人才支持计划(2022LJ-04)。

摘　　要：目的探讨血清脂联素和网膜素-1与冠心病患者发生冠状动脉钙化(CAC)及其严重程度的关系。方法选取2022年6月—2023年6月因胸痛或者胸闷就诊于陕西省人民医院心血管内科并经冠状动脉造影(CAG)、冠状动脉血管内超声(IVUS)检查确诊的冠心病患者192例。收集患者的基线资料(包括年龄、性别、BMI、吸烟史、高血压史、高脂血症史、糖尿病史)、实验室检查指标{包括TC、TG、LDL-C、脂蛋白a[Lp(a)]、血尿酸(SUA)、碱性磷酸酶(ALP)、γ-谷氨酰基转移酶(GGT)、血磷、血钙及血清脂联素、网膜素-1}及IVUS检查结果(包括CAC发生情况和冠心病合并CAC患者钙化指数)。根据CAC发生情况,将患者分为钙化组(发生CAC,n=121)和非钙化组(未发生CAC,n=71)。采用多因素Logistic回归分析探讨冠心病患者发生CAC的影响因素。采用Spearman秩相关分析探讨血清脂联素、网膜素-1与冠心病合并CAC患者钙化指数的相关性。结果钙化组年龄大于非钙化组,有高血压史者占比、有糖尿病史者占比高于非钙化组(P<0.05)。钙化组TG、SUA、ALP、血磷高于非钙化组,血清脂联素、网膜素-1低于非钙化组(P<0.05)。多因素Logistic回归分析结果显示,血清脂联素是冠心病患者发生CAC的影响因素(P<0.05),血清网膜素-1不是冠心病患者发生CAC的影响因素(P>0.05)。Spearman秩相关分析结果显示,血清脂联素与冠心病合并CAC患者钙化指数呈负相关(r_(s)=-0.563,P=0.001),血清网膜素-1与冠心病合并CAC患者钙化指数无直线相关关系(r_(s)=-0.030,P=0.743)。结论血清脂联素是冠心病患者发生CAC的影响因素,且其与患者CAC严重程度呈负相关;血清网膜素-1不是冠心病患者发生CAC的影响因素,且其与患者CAC严重程度无直线相关关系。Objective To investigate the association of serum adiponectin and omentin-1 with coronary artery calcification(CAC)and its severity in patients with coronary heart disease.Methods A total of 192 patients with chest pain or chest tightness who were diagnosed with coronary heart disease by coronary angiography(CAG)and coronary intravascular ultrasound(IVUS)in the Department of Cardiovascular Medicine of Shaanxi Provincial People's Hospital from June 2022 to June 2023 were selected.Baseline data(including age,gender,BMI,smoking history,history of hypertension,hyperlipidemia,and diabetes),laboratory parameters{including TC,TG,LDL-C,lipoprotein a[Lp(a)],serum uric acid(SUA),alkaline phosphatase(ALP),γ-glutamyl transferase(GGT),phosphorus,blood calcium,serum adiponectin and omentin-1}and IVUS results(including occurrence of CAC and calcification index of patients with coronary heart disease and CAC)were collected.The patients were divided into calcification group(with CAC,n=121)and non-calcification group(without CAC,n=71)according to the occurrence of CAC.Multivariate Logistic regression analysis was used to explore the influencing factors of CAC in patients with coronary heart disease.Spearman rank correlation analysis was used to investigate the correlation between serum adiponectin and omentin-1 and calcification index in patients with coronary heart disease and CAC.Results The age in the calcification group was older than that in the non-calcification group,the proportion of patients with history of hypertension,and proportion of patients with history of diabetes in the calcification group were higher than those in the non-calcification group(P<0.05).TG,SUA,ALP and phosphorus in calcification group were higher than those in non-calcification group,and serum adiponectin and omentin-1 were lower than those in non-calcification group(P<0.05).Multivariate Logistic regression analysis showed that serum adiponectin was an influencing factor for CAC in patients with coronary heart disease(P<0.05),and serum omentin-1 was

关 键 词：冠心病 冠状动脉钙化 脂联素 网膜素-1 

分 类 号：R541.4[医药卫生—心血管疾病]