参苓白术散联合针灸治疗肺脾气虚型过敏性鼻炎患者的疗效及对其血清干扰素-γ、白细胞介素-17水平的影响  

Clinical Efficacy of Shenling Baizhu Powder Combined with Acupuncture and Moxibustion on Allergic Rhinitis with Qi Deficiency in Lungs and Spleen Syndrome and Effect on Serum IFN-γand IL-17 Levels

作　　者：赵丽萍 闫春迪 李云雷 张颖 岳远更 ZHAO Li-ping;YAN Chun-di;LI Yun-lei;ZHANG Ying;YUE Yuan-geng(Qinhuangdao Maternal and Child Health Hospital,Qinhuangdao Hebei 066001)

机构地区：[1]秦皇岛市妇幼保健院,河北秦皇岛066001

出　　处：《世界中西医结合杂志》2024年第11期2203-2207,共5页World Journal of Integrated Traditional and Western Medicine

基　　金：秦皇岛市科学技术研究与发展计划(202301A084)。

摘　　要：目的观察参苓白术散联合针灸治疗肺脾气虚型过敏性鼻炎患者的疗效及对其血清干扰素-γ(Interferon-γ,IFN-γ)、白细胞介素-17(Interleukin-17,IL-17)水平的影响。方法选取2020年1月—2023年1月期间秦皇岛市妇幼保健院收治的100例过敏性鼻炎患者,按照随机数字表法分为对照组和观察组,每组各50例。对照组给予参苓白术散口服,观察组在对照组基础上联合针灸治疗。两组患者均持续治疗30 d。观察比较两组患者临床疗效、不良反应情况,治疗前后中医证候积分、血清IFN-γ、IL-17水平及免疫功能水平(CD3^(+)、CD4^(+)、CD8^(+)、CD4^(+)/CD8^(+))。结果治疗后观察组临床总有效率96.00%(48/50)明显高于对照组74.00%(37/50),差异有统计学意义(P<0.05)。治疗后两组患者鼻痒鼻塞、神昏气短、鼻涕清稀、打喷嚏评分均较治疗前明显降低,差异有统计学意义(P<0.05);且观察组鼻痒鼻塞、神昏气短、鼻涕清稀、打喷嚏评分均明显低于对照组,差异有统计学意义(P<0.05)。治疗后两组患者血清IFN-γ水平均较治疗前升高,IL-17水平均较治疗前降低,差异有统计学意义(P<0.05);且观察组IFN-γ水平明显高于对照组,IL-17水平明显低于对照组,差异有统计学意义(P<0.05)。治疗后两组患者CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)水平均较治疗前升高,CD8^(+)水平均较治疗前降低,差异有统计学意义(P<0.05);且观察组CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)水平明显高于对照组,CD8^(+)水平明显低于对照组,差异有统计学意义(P<0.05)。治疗期间,两组患者不良反应发生率比较,差异无统计学意义(P>0.05)。结论参苓白术散联合针灸用于肺脾气虚型过敏性鼻炎患者的疗效显著,能够有效改善患者临床症状,提高血清IFN-γ水平并降低IL-17水平,发挥免疫调节的作用,值得临床推广应用。Objective To observe the efficacy of Shenling Baizhu Powder combined with acupuncture and moxibustion in allergic rhinitis patients with lung-spleen qi deficiency syndrome and its effect on serum levels of interferonγ(IFN-γ)and interleukin-17(IL-17).Methods A total of 100 allergic rhinitis patients admitted to Qinhuangdao Maternal and Child Health Hospital from January 2020 to January 2023 were enrolled and randomly divided into a control group and an observation group according to a random number table,with 50 patients in each group.The control group received oral Shenling Baizhu Powder,while the observation group received acupuncture and moxibustion in addition to the control treatment.Both groups underwent treatment for 30 days.Clinical efficacy,adverse reactions,traditional Chinese medicine(TCM)syndrome scores,serum IFN-γand IL-17 levels,and immune function levels[CD3^(+),CD4^(+),CD8^(+),CD4^(+)/CD8^(+)]before and after treatment were compared.Results The clinical total effective rate in the observation group was 96.00%(48/50),significantly higher than 74.00%(37/50)in the control group(P<0.05).After treatment,scores for nasal itching,nasal congestion,shortness of breath,runny nose,and sneezing significantly decreased in both groups compared to those before treatment(P<0.05),with the observation group scoring lower than the control group(P<0.05).Serum IFN-γlevels increased and IL-17 levels decreased in both groups after treatment(P<0.05),and the observation group had significantly higher IFN-γlevels and lower IL-17 levels than the control group(P<0.05).Immune function levels(CD3^(+),CD4^(+),CD4^(+)/CD8^(+))increased,while CD8^(+)levels decreased in both groups after treatment(P<0.05),and the observation group had significantly higher CD3^(+),CD4^(+),and CD4^(+)/CD8^(+)levels and lower CD8^(+)levels than the control group(P<0.05).There were no significant differences in adverse reaction rates between the two groups during treatment(P>0.05).Conclusion Shenling Baizhu Powder combined with acupuncture and mox

关 键 词：参苓白术散 针灸 过敏性鼻炎 干扰素-Γ 白细胞介素-17 

分 类 号：R245[医药卫生—针灸推拿学] R765.21[医药卫生—中医临床基础]