风咳浓煎剂治疗呼吸道感染后咳嗽患者的疗效及对其气道炎症的影响  

Efficacy of Fengke Nongjian Decoction in Treatment of Postinfectious Cough after Respiratory Tract Infection and Influence on Airway Inflammation

作　　者：杨雯 祝宇涛 马志豪 高戎[1] 杨润华[2] YANG Wen;ZHU Yu-tao;MA Zhi-hao;GAO Rong;YANG Run-hua(Emergency Department of Nanjing Integrated Traditional Chinese and Western Medicine Hospital Affiliated to Nanjing University of Chinese Medicine,Nanjing Jiangsu 210014;Intensive Care Unit of Nanjing Integrated Traditional Chinese and Western Medicine Hospital Affiliated to Nanjing University of Chinese Medicine,Nanjing Jiangsu 210014)

机构地区：[1]南京中医药大学附属南京市中西医结合医院急诊科,江苏南京210014 [2]南京中医药大学附属南京市中西医结合医院重症医学科,江苏南京210014

出　　处：《世界中西医结合杂志》2024年第11期2291-2296,共6页World Journal of Integrated Traditional and Western Medicine

基　　金：南京市中西医结合医院院内课题(SZX202304)。

摘　　要：目的观察风咳浓煎剂治疗呼吸道感染后咳嗽(Postinfectious cough,PIC)患者的疗效及对其气道炎症的影响。方法选取2021年1月—2023年6月期间南京中医药大学附属南京市中西医结合医院收治的呼吸道PIC患者122例,按随机数字表法分为观察组与对照组,每组各61例。对照组接受常规西药治疗,观察组在对照组基础上加用风咳浓煎剂治疗。治疗10 d后,观察比较两组患者临床疗效、临床症状缓解及不良反应情况,治疗前后中医证候评分、视觉模拟量表(Visual analogue scale,VAS)、简易咳嗽程度评分表(Cough evaluation test,CET)、莱切斯特咳嗽问卷(Leicester cough questionnaire,LCQ)、炎症相关指标[血清白介素-6(Interleukin-6,IL-6)、白介素-8(Interleukin-8,IL-8)、肿瘤坏死因子α(Tumor necrosis factor-α,TNF-α)、P物质(Substance P,SP)]。结果治疗后观察组患者咳嗽、咳痰、咽痒、气喘消失时间明显优于对照组,差异有统计学意义(P<0.05)。治疗后两组患者咳嗽、咽干咽痒、咳痰、气急及总评分均较治疗前降低,差异有统计学意义(P<0.05);且观察组咳嗽、咽干咽痒、咳痰、气急及总评分均较对照组明显降低,差异有统计学意义(P<0.05)。治疗后两组患者咳嗽VAS和CET评分均较治疗前降低,差异有统计学意义(P<0.05);且观察组咳嗽VAS和CET评分均较对照组明显降低,差异有统计学意义(P<0.05)。治疗后两组患者LCQ评分均较治疗前升高,差异有统计学意义(P<0.05);且观察组LCQ评分较对照组明显升高,差异有统计学意义(P<0.05)。治疗后两组患者SP、IL-6、IL-8及TNF-α水平均较治疗前降低,差异有统计学意义(P<0.05);且观察组SP、IL-6、IL-8及TNF-α水平均较对照组明显降低,差异有统计学意义(P<0.05)。治疗后观察组总有效率98.28%(57/58)、愈显率86.21%(50/58)明显优于对照组总有效率86.67%(52/60)、愈显率63.33%(38/60),差异有统计学意义(χ^(2)=4.114、8.138,P<0.05)。�Objective To observe the clinical efficacy of Fengke Nongjian Decoction in the treatment of postinfectious cough(PIC)after respiratory tract infection and its impact on airway inflammation.Methods A total of 122 patients with respiratory PIC,treated at the Nanjing Integrated Traditional Chinese and Western Medicine Hospital Affiliated to Nanjing University of Chinese Medicine from January 2021 to June 2023,were selected and randomly divided into two groups:an observation group and a control group according to a random number table,with 61 patients in each group.The control group received conventional Western medication,while the observation group was treated with Fengke Nongjian Decoction in addition to the conventional treatment.After 10 days of treatment,clinical efficacy,symptom relief,adverse reactions,traditional Chinese medicine(TCM)syndrome scores,Visual Analogue Scale(VAS)scores,Cough Evaluation Test(CET)scores,Leicester Cough Questionnaire(LCQ)scores,and inflammatory markers[serum interleukin-6(IL-6),interleukin-8(IL-8),tumor necrosis factor-α(TNF-α),substance P(SP)]befone and after treatment were compared between the two groups.Results After treatment,the obeervation group showed significantly faster disappearance of symptoms such的cough,ex-pectoration,throat ithing,and wheexi ng than the contol group(P<0.05).Both groups had sinificant reductions in symp-toms such as cough,hroat dryness and ithing,expectonation,and shortness of breath,as welltotal soores,after treatment(P<0.05).The obeervation group showed lower sores of oough,throat dryness and ithing,expectoration,and shortness of breath,as welltotal scone,than the control group(P<0.05).Both goups also exhibited a sigificant reduction in cough VAS and CET soones after treatment(P<0.05),with the obsevation group showing greater neductions than the control group(P<0.05).L0Q sores increased signifcantly in both groups aftr treatment(P<0.05),with the obsevation group showing a more substantial increase than the control group(P<0.05).Inflammatory markes

关 键 词：呼吸道感染 感染后咳嗽 风咳浓煎剂 气道炎症 

分 类 号：R256.11[医药卫生—中医内科学]