自噬在胃肠动力障碍中的作用及中医药干预研究进展  

The role of autophagy in gastrointestinal motility disorders and the progress of herbal intervention

作　　者：陈月莹 徐明瑶 谢胜[2] 黎丽群 CHEN Yueying;XU Mingyao;XIE Sheng;LI Liqun(Graduate School of Guangxi University of Traditional Chinese Medicine,Nanning 530001,Guangxi,China;The First Affiliated Hospital of Guangxi University of Traditional Chinese Medicine,Nanning 530001,Guangxi,China)

机构地区：[1]广西中医药大学研究生学院,广西南宁530001 [2]广西中医药大学第一附属医院,广西南宁530001

出　　处：《实用中医内科杂志》2024年第12期14-19,I0014,共7页Journal of Practical Traditional Chinese Internal Medicine

基　　金：国家自然科学基金青年科学基金项目(82004299);广西科技基地和人才专项(桂科AD19245168);广西科技厅自然科学基金青年基金项目(2021GXNSFBA196055)。

摘　　要：胃肠动力障碍(Gastrointestinal Motility Disorders,GMD)是一类由胃肠动力紊乱引起的病症,该类病症全球发病率居高不下,疾病范围广泛,严重影响患者的身心健康。该病病理机制尚未完全明确,与动力障碍、高敏反应、代谢紊乱等密切相关,其中动力障碍是GMD主要的病理基础。细胞自噬是一种通过清除损坏细胞器及异常蛋白质来维持能量代谢平衡及内环境稳定的保护机制。大量研究证实,自噬在GMD发病中起关键作用,中医药能够调控PI3K/AKT/mTOR、Pink1/Parkin等多条自噬相关信号通路抑制胃肠细胞自噬,发挥保护胃肠细胞、恢复胃肠动力等作用,正成为GMD潜在的治疗策略。目前中医药通过调控自噬治疗GMD已取得了较好的进展,但尚未有系统阐述。因此,该文就自噬与GMD之间的相关性、中医药调控自噬干预GMD的作用机制进行系统性总结,旨在为中医药对GMD的治疗及新药研发提供新思考。Gastrointestinal Motility Disorders(GMD)is a group of disorders caused by gastrointestinal motility disorders,which have a high global incidence and a wide range of diseases,and seriously affect the physical and mental health of patients.The pathological mechanism of this disease is not fully understood,and is closely related to dysmotility,hypersensitivity and met⁃abolic disorders,among which dysmotility is the main pathological basis of GMD.Cellular autophagy is a protective mechanism to maintain energy metabolic homeostasis and internal environment stability by removing damaged organelles and abnormal proteins.A large number of studies have confirmed that autophagy plays a key role in the pathogenesis of GMD,and TCM can regulate sev⁃eral autophagy-related signaling pathways such as PI3K/AKT/mTOR、Pink1/Parkinto inhibit autophagy in gastrointestinal cells and play a role in protecting gastrointestinal cells and restoring gastrointestinal motility,which is becoming a potential therapeutic strategy for GMD.At present,Chinese medicine has made good progress in treating GMD by regulating autophagy,but it has not been systematically elaborated.Therefore,this paper provides a systematic summary of the correlation between autophagy and GMD and the mechanism of action of TCM in regulating autophagy to intervene in GMD,aiming to provide new thinking for the treatment of GMD and new drug development in TCM.

关 键 词：胃肠动力障碍 自噬 中医药 研究进展 

分 类 号：R259[医药卫生—中西医结合]