胆汁酸-肠道激素轴调控2型糖尿病的作用机制及中医药研究进展  

Mechanism of Bile Acid-Intestinal Hormone Axis Regulating Type 2 Diabetes Mellitus and Research Progress in Traditional Chinese Medicine

作　　者：马朝晖 张东鹏[2] 罗江卫 曲静 张莉莉 冯媛媛 MA Zhaohui;ZHANG Dongpeng;LUO Jiangwei;QU Jing;ZHANG Lili;FENG Yuanyuan(Gansu University of Chinese Medicine,Lanzhou 730000,Gansu,China;Gansu Provincial Hospital of Traditional Chinese Medicine,Lanzhou 730050,Gansu,China;The First People's Hospital of Wudu District,Longnan 746099,Gansu,China)

机构地区：[1]甘肃中医药大学,甘肃兰州730000 [2]甘肃省中医院,甘肃兰州730050 [3]陇南市武都区第一人民医院,甘肃陇南746099

出　　处：《实用中医内科杂志》2024年第12期66-71,共6页Journal of Practical Traditional Chinese Internal Medicine

基　　金：国家自然科学基金项目(82360955);国家中医优势专科建设项目(甘卫中医函[2023]63号);甘肃省中医药管理局(GZK-2019-7);甘肃省科技厅重点研发项目(20YF8FA089)。

摘　　要：胆汁酸对促进肠道脂肪的消化和维持体内胆固醇代谢稳态起重要作用。近些年研究表明,胆汁酸能作为信号分子,分别激活核受体和膜受体,促进肠道激素成纤维细胞生长因子19及胰高血糖素样肽-1的分泌,对机体葡萄糖调节发挥作用。胆汁酸谱的变化与胰岛素抵抗和2型糖尿病的发病机制有关,法尼醇X受体和G蛋白偶联胆汁酸受体-5已被证明能调整胆汁酸代谢。该文从胆汁酸-肠道激素轴角度探讨了其调控2型糖尿病的作用机制,并从中医理论,中药单体/提取物,中药复方等角度进行了相关文献综述,旨在为2型糖尿病的治疗提供新思路。Bile acids play an important role in promoting the digestion of intestinal fat and maintaining cholesterol metabolic homeostasis in the body.Recent studies have shown that bile acids can act as signaling molecules to activate nuclear receptors and membrane receptors respectively,promoting the secretion of intestinal hormones fibroblast growth factor 19 and glucagon like peptide-1 and playing a role in the regulation of glucose in the body.Changes in the bile acid profile have been implicated in the pathogenesis of insulin resistance and type 2 diabetes,and farnesoid X receptor and G protein-coupled bile acid receptor-5 have been shown to modulate bile acid metabolism.In this paper,the mechanism of action of bile acid-intestinal hormone axis in regulating type 2 diabetes was discussed,and relevant literature reviews were conducted from the perspectives of traditional Chinese medicine(TCM)theory,TCM monomer/extract and TCM compound,aiming to provide new ideas for the treatment of type 2 diabetes.

关 键 词：胆汁酸 肠道激素 2型糖尿病 中医药 

分 类 号：R259[医药卫生—中西医结合]