杞菊地黄丸联合抗VEGF通过调控cAMP/PKA信号通路治疗增殖性糖尿病视网膜病变的作用机制  

Mechanism Analysis of Qiju Dihuang Pill combined with Anti-VEGF in the Treatment of Proliferative Diabetic Retinopathy by Regulating cAMP/PKA Signaling Pathway

作　　者：王雨晴 张招德 李晓清 林淑华 林凌莉 WANG Yuqing;ZHANG Zhaode;LI Xiaoqing;LIN Shuhua;LIN Lingli(Ningde Municipal Hospital of Ningde Normal University,Ningde 352100,Fujian,China)

机构地区：[1]宁德师范学院附属宁德市医院,福建宁德352100

出　　处：《实用中医内科杂志》2024年第12期126-128,共3页Journal of Practical Traditional Chinese Internal Medicine

基　　金：福建省自然科学基金联合资金项目(2022J011218)。

摘　　要：目的研究旨在探讨杞菊地黄丸联合抗VEGF通过调控cAMP/PKA信号通路治疗增殖性糖尿病视网膜病变患者的作用机制。方法将2022年1月—2024年3月宁德师范学院附属宁德市医院眼科收治的204例增殖性糖尿病视网膜病变患者为研究对象,采用随机数字表法将其分为对照组(给予抗VEGF治疗)和试验组(给予杞菊地黄丸联合抗VEGF治疗)各102例,对比两组疗效,观察治疗前、治疗后视力相关指标、VEGF、Ang-1水平及cAMP/PKA信号通路。结果试验组总有效率高于对照组(P<0.05)。治疗后两组眼部相关指标(视力、眼压、视野灰度值、黄斑中心凹厚度)水平均优于治疗前(P<0.05);试验组眼部相关指标(视力、眼压、视野灰度值、黄斑中心凹厚度)水平优于对照组(P<0.05)。治疗后两组VEGF、Ang-1水平低于治疗前(P<0.05);试验组VEGF、Ang-1水平低于对照组(P<0.05)。治疗后两组cAMP水平高于治疗前,PKA水平低于治疗前(P<0.05);试验组cAMP水平高于治疗前,PKA水平低于对照组(P<0.05)。结论杞菊地黄丸联合抗VEGF能够通过调控cAMP/PKA信号通路,发挥治疗增殖性糖尿病视网膜病变患者的作用。Objective The aim of this study was to investigate the mechanism of Qiju Dihuang Pill combined with anti-VEGF in the treatment of proliferative diabetic retinopathy by regulating cAMP/PKA signaling pathway.Methods A total of 204 patients with proliferative diabetic retinopathy admitted to the Ophthalmology Department of Ningde Hospital,Affiliated to Ningde Normal University from January 2022 to March 2024 were selected as the study objects,and were divided into control group(given anti VEGF treatment)and experimental group(given Qiju Dihuang pill combined with anti-VEGF treatment)with 102 cases each by random number table method.The efficacy of the two groups was compared.The vision-related indexes,levels of VEGF,Ang-1 and cAMP/PKA signaling pathway were observed before and after treatment.Results The total effective rate of experimental group was higher than that of control group(P<0.05).After treatment,the eye-related indexes(visual acuity,IOP,visual field gray value,macular fovea thickness)in both groups were better than before treatment(P<0.05).The levels of eye related indexes(visual acuity,IOP,visual field gray value,macular fovea thickness)in experimental group were better than those in control group(P<0.05).The levels of VEGF and Ang-1 after treatment were lower than those before treatment(P<0.05).The levels of VEGF and Ang-1 in experimental groups were lower than those in control group(P<0.05).After treatment,cAMP level was higher than before treatment,PKA level was lower than before treatment(P<0.05).cAMP level in experimen⁃tal group was higher than before treatment,PKA level was lower than control group(P<0.05).Conclusion Qiju Dihuang Pill combined with anti-VEGF can regulate cAMP/PKA signaling pathway and play a role in the treatment of proliferative diabetic retinopathy patients.

关 键 词：杞菊地黄丸 抗VEGF 增殖性糖尿病视网膜病变 cAMP/PKA信号通路 

分 类 号：R587.2[医药卫生—内分泌] R774.1[医药卫生—内科学]