纳米药物在非酒精性脂肪性肝病治疗中的研究现状  

Research status of nano-drugs in the treatment of non-alcoholic fatty liver disease

作　　者：丘炜桉 章波 张裕彦 朱煜 郭魏 刘悦 叶勇[1,3] QIU Wei-an;ZHANG Bo;ZHANG Yu-yan;ZHU Yu;GUO Wei;LIU Yue;YE Yong(College of Pharmacy,Guangxi Medical University,Nanning 530021,Guangxi Zhuang Autonomous Region,China;School of Pharmacy,Naval Medical University,Shanghai 200433,China;Guangxi Key Laboratory of Bioactive Molecules Research and Evaluation,Nanning 530021,Guangxi Zhuang Autonomous Region,China)

机构地区：[1]广西医科大学药学院,广西壮族自治区南宁530021 [2]海军军医大学药学系,上海200433 [3]广西生物活性分子研究与评价重点实验室,广西壮族自治区南宁530021

出　　处：《中国临床药理学杂志》2024年第23期3482-3486,共5页The Chinese Journal of Clinical Pharmacology

基　　金：国家自然科学基金资助项目(82360818,81960756);广西自然科学基金资助项目(2022GXNSFDA035063,2023GXNSFAA026366)。

摘　　要：非酒精性脂肪性肝病(NAFLD)已成为当前全球最常见的肝病之一,其发病机制复杂,现有的治疗策略仍然无法完全逆转NAFLD的进展。近年来,随着纳米技术和纳米医学的不断发展,纳米药物以其安全、稳定、缓释、靶向等特性正逐步成为治疗NAFLD的新兴策略。目前,纳米药物在治疗NAFLD机制上的主要关注点是脂质代谢、胰岛素抵抗和氧化应激,鲜有研究联合NAFLD发病机制中的不同靶点和信号通路以工程化设计纳米药物。本综述着重于肝疾病治疗领域,并对围绕纳米药物系统包括纳米晶体、脂质纳米颗粒、聚合物纳米颗粒、胶束等开展的NAFLD治疗研究进行总结阐述,以期对该领域的相关实验研究与药物开发提供一定的思路和指导。Non-alcoholic fatty liver disease(NAFLD)has become one of the most common liver diseases in the world.Its pathogenesis is complex,and the current treatment strategies still cannot completely reverse the progression of NAFLD.In recent years,with the continuous development of nanotechnology and nanomedicine,nano-drugs is gradually becoming a new strategy for the treatment of NAFLD due to its safety,stability,slow release and targeting characteristics.At present,the main focus of nano-drugs on the mechanism of NAFLD is lipid metabolism,insulin resistance and oxidative stress,and few studies have been conducted to engineer nano-drugs by combining different targets and signaling pathways in the pathogenesis of NAFLD.This review focuses on the treatment of liver diseases,and summarizes and expounds the therapeutic research on NAFLD surrounding nano-drugs systems,including nanocrystals,lipid nanoparticles,polymer nanoparticles,micelles,etc.,in order to provide certain ideas and guidance for relevant experimental research and drug development in this field.

关 键 词：纳米药物 非酒精性脂肪性肝病 药物治疗 药物递送 药物载体 

分 类 号：R97[医药卫生—药品]