细胞程序性死亡在急性胰腺炎发病机制中的研究现状  

Research status of programmed cell death in pathogenesis of acute pancreatitis

作　　者：张钰 白敏 汪湛东 连源 王琼[1] 宋冰 郭超[1,4] 汪永锋 张延英[1,4] ZHANG Yu;BAI Min;WANG Zhan-dong;LIAN Yuan;WANG Qiong;SONG Bing;GUO Chao;WANG Yong-feng;ZHANG Yan-ying(First School of Clinical Medicine,Gansu University of Chinese Medicine,Lanzhou 730000,Gansu Province,China;School of Basic Medicine,Gansu University of Chinese Medicine,Lanzhou 730000,Gansu Province,China;College of Integrative Chinese and Western Medicine,Gansu University of Chinese Medicine,Lanzhou 730000,Gansu Province,China;Gansu Provincial Laboratory Animal Industry Technology Center,Lanzhou 730000,Gansu Province,China;School of Basic Medicine,Gansu Medical College,Pingliang 744000,Gansu Province,China)

机构地区：[1]甘肃中医药大学第一临床医学院,甘肃兰州730000 [2]甘肃中医药大学.基础医学院,甘肃兰州730000 [3]甘肃中医药大学中西医结合学院,甘肃兰州730000 [4]甘肃省实验动物行业技术中心,甘肃兰州730000 [5]甘肃医学院基础医学院,甘肃平凉744000

出　　处：《中国临床药理学杂志》2024年第23期3492-3496,共5页The Chinese Journal of Clinical Pharmacology

基　　金：国家自然科学基金资助项目(82360898,82160871);甘肃省自然科学基金资助项目(22JR5RA591);甘肃省中医药管理局重点基金资助项目(GZKZ-2021-10)。

摘　　要：急性胰腺炎(AP)是临床常见危重性疾病之一。胰腺腺泡细胞死亡是AP病理过程的中心事件,也是决定局部或全身炎症损伤程度以及整体预后的关键因素。细胞程序性死亡普遍存在于生物体发育过程中,是受程序调控且主动有序的死亡方式。多种程序性死亡模式广泛参与了AP腺泡细胞的损伤,主要包括自噬、焦亡和铁死亡等。本研究就程序性死亡在AP腺泡细胞中的作用机制进行综述,旨在为AP的具体发病机制提供新的认识,为疾病治疗提供新的思路和策略。Acute pancreatitis(AP)is one of the most common clinically critical diseases,and pancreatic acinar cell death is a central event in the pathological course of AP and a key factor in determining the degree of local or systemic inflammatory damage as well as overall pancreatitis.Programmed cell death is an active and orderly way of death that is regulated by program and widely exists in the development of organisms.A variety of programmed death modes are widely involved in the damage of AP acinar cells,mainly including autophagy,pyrodeath and iron death,etc.This study systematically reviews the mechanism of programmed death in AP acinar cells.The aim is to provide a new understanding of the specific pathogenesis of AP,and to provide new ideas and strategies for the treatment of the disease.

关 键 词：急性胰腺炎 细胞程序性死亡 腺泡细胞 

分 类 号：R97[医药卫生—药品]