细菌纳米纤维素制备小口径人工血管的研究进展  

Research progress on bacterial nanocellulose in the preparation of small-diameter artificial blood vessels

作　　者：孙运平 邓华 张静[2,3,4] 黄萃园 李文强 刘丽[2,3,4] 王伟 杨简 SUN Yunping;DENG Hua;ZHANG Jing;HUANG Cuiyuan;LI Wenqiang;LIU Li;WANG Wei;YANG Jian(Department of Cardiovascular Medicine,the First Clinical Medical College of Three Gorges University/Yichang Central People′s Hospital,Yichang,Hubei,443000;Center Laboratory,the First Clinical Medical College of Three Gorges University/Yichang Central People′s Hospital,Yichang,Hubei,443000;Hubei Key Laboratory of Ischemic Cardiovascular Diseases,Yichang,Hubei,443000;Hubei Clinical Medical Research Center for Ischemic Cardiovascular Diseases of Hubei Province,Yichang,Hubei,443000;Hubei Three Gorges Laboratory,Yichang,Hubei,443000)

机构地区：[1]三峡大学第一临床医学院/湖北省宜昌市中心人民医院心血管内科,湖北宜昌443000 [2]三峡大学第一临床医学院/湖北省宜昌市中心人民医院,中心实验室,湖北宜昌443000 [3]缺血性心血管病湖北省重点实验室,湖北宜昌443000 [4]湖北省缺血性心血管疾病临床医学研究中心,湖北宜昌443000 [5]湖北三峡实验室,湖北宜昌443000

出　　处：《实用临床医药杂志》2024年第22期132-136,142,共6页Journal of Clinical Medicine in Practice

基　　金：国家自然科学基金项目(82070372,82170418,82271618);湖北省自然科学基金创新群体项目(2022CFA015);湖北省科技创新基地条件平台专项(2022DCC014);湖北省重点研发计划(2022BCE001);湖北省卫生健康委面上项目(WJ2023M151);湖北三峡实验室开放基金项目(SK231001)。

摘　　要：人工血管作为一种重要的血管替代物,已被广泛应用于血管介入治疗和血管重建手术中。小口径人工血管(直径<6 mm)由于口径小、流速慢、血压低、血流环境复杂等原因,长期植入时仍面临一些挑战。细菌纳米纤维素(BNC)作为一种天然高分子材料,通过复合改性和表面修饰增强小口径人工血管的再生作用和修复效果。本文综述了BNC制备小口径人工血管的研究进展,并讨论了BNC修饰人工血管的优势和潜在应用前景。Artificial blood vessels,serving as crucial vascular substitutes,have been widely utilized in vascular interventional therapies and revascularization surgeries.Small-diameter artificial blood vessels(diameter<6 mm)pose challenges for long-term implantation due to their small diameter,slow flow velocity,low blood pressure,and complex blood flow environment.Bacterial nanocellulose(BNC),a natural polymer material,enhances the regenerative and repair effects of small-diameter artificial blood vessels through composite modification and surface modification.This article reviewed the research progress in the preparation of small-diameter artificial blood vessels using BNC and discussed the advantages and potential application prospects of BNC artificial blood vessels.

关 键 词：血管 心血管疾病 人工血管 细菌纳米纤维素 生物材料 组织工程 

分 类 号：R34[医药卫生—基础医学] R543.5R456