An Asymmetric Natural Nanofiber with Rapid Temperature Responsive Detachability Inspired by Andrias davidianus for Full‑Thickness Skin Wound Healing  

作　　者：Zhe Huang Heng An Haitao Guo Shen Ji Qi Gu Zhen Gu Yongqiang Wen 

机构地区：[1]School of Chemistry and Biological Engineering,University of Science and Technology Beijing,Haidian District,Beijing 100083,China [2]State Key Laboratory of Membrane Biology,Institute of Zoology,Chinese Academy of Sciences,Chaoyang District,Beijing 100101,China [3]Beijing Institute for Stem Cell and Regenerative Medicine,Chaoyang District,Beijing 100101,China [4]University of Chinese Academy of Sciences,Huairou District,Beijing 100049,China

出　　处：《Advanced Fiber Materials》2024年第2期473-488,共16页先进纤维材料（英文）

基　　金：supported by the National Natural Science Foundation of China(52273120,21975019,T2222029,and U21A20396);CAS Project for Young Scientists in Basic Research(YSBR-012);Incubation Foundation of Beijing Institute for Stem Cell and Regenerative Medicine(2022FH125,2023FH122)and,the China Scholarship Council(No.202206465017);the Fundamental Research Funds for the Central Universities(FRFTP-20-019A2,FRF-BR-20-03B);the Project was supported by the Science Fund of Shandong Laboratory of Advanced Materials and Green Manufacturing(Yantai)(AMGM2023F04);the Strategic Priority Research Program of the Chinese Academy of Sciences(XDA16020802).

摘　　要：Wound dressing management is critical in healthcare,and frequent dressing changes for full-thickness skin wounds can hinder healing.Nanofiber dressings that resemble the extracellular matrix,have gained popularity in wound repair,however,it is challenging to explore how to frequently change it without affecting healing processing and avoiding secondary damage.Here,we developed a self-adhesive and detachable nanofiber dressing inspired by Andrias davidianus.Our asymmetric nanofiber dressing exhibits strong adhesion(26 kPa),to the wound at high temperature(approximately 25°C)to the wound surface and can be easily detached(4 kPa)at low temperature(below 8°C),enabling painless dressing changes that minimize secondary injuries.The dressing comprises an outer layer of polylactic acid which provides mechanical property,support,and pollution resistance,with an inner layer of nanofibrous membrane,composed of gelatin and Andrias davidianus skin secretions,which promotes cellular migration,enhances wound healing and possesses inherent antimicrobial properties.Furthermore,the all-natural nanofiber dressings can be prepared on a large scale and offer favorable biocompatibility to meet the basic requirements of wound dressings.These findings demonstrate the potential applicability of our multilayer nanofiber dressing for advancing wound healing practices.

关 键 词：NATURAL RAPID Temperature Responsive Detachability ASYMMETRIC Nanofibers Bionic Wound Healing 

分 类 号：TB383[一般工业技术—材料科学与工程]