Low‑Temperature Trigger Nitric Oxide Nanogenerators for Anti‑biofilm and Wound Healing  

作　　者：Lefeng Su Chenle Dong Lei Liu Yanping Feng Jinfeng Xu Qinfei Ke Jiang Chang Chen Yang He Xu 

机构地区：[1]Shanghai Key Laboratory of Rare Earth Functional Materials,Shanghai Frontiers Science Center of Biomimetic Catalysis,Shanghai Normal University,Shanghai 200234,People’s Republic of China [2]Joint Centre of Translational Medicine,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou 325000,People’s Republic of China [3]State Key Laboratory of High Performance Ceramics and Superfine Microstructure,Shanghai Institute of Ceramics,Chinese Academy of Sciences,Shanghai 200050,People’s Republic of China [4]Wenzhou Institute,Zhejiang Engineering Research Center for Tissue Repair Materials,University of Chinese Academy of Sciences,Wenzhou 325000,People’s Republic of China

出　　处：《Advanced Fiber Materials》2024年第2期512-528,共17页先进纤维材料（英文）

基　　金：supported by the National Natural Science Foundation of China(Grant No.32271386);Zhejiang Engineering Research Center for Tissue Repair Materials(Grant No:WIUCASZZXF21001);Wenzhou Science and Technology Major Project(ZY2022028);Wenzhou Science and Technology Project(Y20220142);the seed grants from the Wenzhou Institute,University of Chinese Academy of Sciences(WIUCASQD2020013,WIUCASQD2021030);the Opening Project of State Key Laboratory of High Performance Ceramics and Superfine Microstructure(Grant Nos:SKL-202112SIC,SKL202213SIC);the founding from First Affiliated Hospital of Wenzhou Medical University.

摘　　要：Infected wounds pose a significant global health challenge due to the persistence of bacterial biofilms and limited tissue self-repair.Nitric oxide(NO)functions as a potent antimicrobial agent,demonstrating a dual capacity for both antimicrobial action and tissue rejuvenation across varying concentrations.However,achieving controlled NO release at distinct stages of infected wound progression,simultaneously targeting biofilm removal and wound recovery,remains a formidable challenge.In this work,we introduce a smart electrospun fibrous membrane,featuring an interior laden with NO-loaded HKUST-1 particles and a porous external surface.Notably,the results reveal the photothermal property of HKUST-1 when exposed to near-infrared(NIR)light,enabling precise management of NO release contingent upon light conditions.During the initial phase of infection treatment,a significant NO release is triggered by near-infrared photothermal stimulation,synergistically complementing photothermal therapy to effectively eliminate bacterial biofilms.Subsequently,in the wound-healing phase,NO is released from the degrading fibrous membrane in a controlled and gradual manner,synergizing with trace amounts of copper ions released during MOF degradation.This collaborative mechanism accelerates the formation of blood vessels within the wound,thereby facilitating the healing process.This study suggests a promising and innovative approach for the effective treatment of infected wounds.

关 键 词：Nitric oxide(NO) Electrospinning Photothermal effect Anti-biofilm Infected wounds’healing 

分 类 号：R318[医药卫生—生物医学工程]