Electrospun trilayer eccentric Janus nanofibers for a combined treatment of periodontitis  

作　　者：Ping Zhao Kecong Zhou Yiru Xia Cheng Qian Deng‑Guang Yu Yufeng Xie Yaozu Liao 

机构地区：[1]School of Materials and Chemistry,University of Shanghai for Science and Technology,Shanghai 200093,China [2]Department of Periodontology,Shanghai Ninth People’s Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200023,China [3]Shanghai Key Laboratory of Stomatology and Shanghai Research Institute of Stomatology,National Clinical Research Center for Oral Diseases,Shanghai 200023,China [4]Shanghai Engineering Research Center of Advanced Dental Technology and Materials,Shanghai 20023,China [5]College of Materials Science and Engineering,State Key Laboratory of Modifications On Chemical Fibers and Polymer Materials,Donghua University,Shanghai 201620,China [6]Department of Periodontology,Shanghai Stomatological Hospital and School of Stomatology,Fudan University,Shanghai 200001,China [7]Shanghai Key Laboratory of Craniomaxillofacial Development and Diseases,Fudan University,Shanghai 200001,China

出　　处：《Advanced Fiber Materials》2024年第4期1053-1073,共21页先进纤维材料（英文）

基　　金：supported by the Medical-Engineering Cross Project between University of Shanghai for Science and technology and Shanghai Jiaotong University(No.202130071);the Shanghai Industrial Collaboration Project(HCXBCY-2023-042 and XTCX-KJ-2023-44).

摘　　要：Oral diseases are common and prevalent,affecting people's health and seriously impairing their quality of life.The implantable class of materials for a safe,convenient,and comprehensive cure of periodontitis is highly desired.This study shows a proof-of-concept demonstration about the implant fibrous membranes.The fibers having a trilayer eccentric side-by-side structure are fabricated using the multiple-fluid electrospinning,and are fine candidates for treating periodontitis.In the trilayer eccentric side-by-side composite nanofibers,the outermost layer contains a hydrophilic polymer and a drug called ketoprofen,which can reach a release of 50%within 0.37 h,providing a rapid pain relief and anti-inflammatory effect.The middle layer is loaded with metronidazole,which is manipulated to be released in a sustained manner.The innermost layer is loaded with nano-hydroxyapatite,which can directly contact with periodontal tissues to achieve the effect of promoting alveolar bone growth.The experimental results indicate that the developed implant films have good wettability,fine mechanical properties,biodegradability,and excellent antibacterial properties.The implant films can reduce inflammatory responses and promote osteoblast formation by down-regulating interleukin 6 and up-regulating osteoprotegerin expression.In addition,their composite nanostructures exhibit the desired promotional effects on fibroblast attachment,infiltration,proliferation,and differentiation.Overall,the developed fibrous implant films show strong potential for use in a combined treatment of periodontitis.The protocols reported here pave a new way to develop multi-chamber based advanced fiber materials for realizing the desired functional performances through a robust process-structure-performance relationship.

关 键 词：Trilayer Janus nanofibers Side-by-side electrospinning PERIODONTITIS Combined treatment Medical implants Multifunctional 

分 类 号：R318.08[医药卫生—生物医学工程] R78[医药卫生—基础医学]