Multifunctional and Sprayable 2D MoS_(2)/Silk Sericin Bio‑Nanocomposite Dressings with Enhanced Photothermal Effect for Infected Wound Healing  

作　　者：Libin Qiu Lian Duan Hongyu Lin Min Wang Huaping Liang Guilong Peng Xiao Yang Yang Si Shixiong Yi 

机构地区：[1]State Key Laboratory of Resource Insects,College of Sericulture,Textile and Biomass Sciences,Southwest University,Chongqing 400715,People’s Republic of China [2]Institute for Clean Energy and Advanced Materials,School of Materials and Energy,Southwest University,Chongqing 400715,People’s Republic of China [3]State Key Laboratory of Trauma,Burns and Combined Injury,Research Institute of Surgery,Daping Hospital,Third Military Medical University,Chongqing 400042,People’s Republic of China [4]Innovation Center for Textile Science and Technology,Donghua University,Shanghai 200051,People’s Republic of China

出　　处：《Advanced Fiber Materials》2024年第4期1074-1091,共18页先进纤维材料（英文）

基　　金：supported by the National Natural Science Foundation of China(No.22008201);Natural Science Foundation Innovation and Development Joint Fund Project of Chongqing(No.CSTB2023NSCQ-LZX0028);Fundamental Research Funds for the Central Universities(No.SWU-KW22004);Special Program Project(No.2022-JCJQ-ZD-224-12);Open Project Program of the Ministry of Education of the Key Laboratory of Textile Fiber and Products(No.Fzxw2021001).

摘　　要：Developing novel antibacterial dressing protecting skin injuries from infection is essential for wound healing.In this study,sericin,a bio-waste produced during the degumming of silk cocoons,is utilized to exfoliate MoS_(2)layers and improve the dispersity and stability of MoS_(2)nanosheets(MoS_(2)-NSs).Moreover,owing to its ability to promote oxygen permeability and cell growth and its good biocompatibility,MoS_(2)-NS/Sericin maintains its photothermal property under an 808 nm light source for a strong antibacterial activity as well as improves the fibroblast migration,which accelerates wound healing.Fur-thermore,the in vitro experiments indicates that MoS_(2)-NS/Sericin can also scavenge reactive oxygen species(ROS)at an inflammatory stage of wound healing and transform classical activated macrophages(M1-type)into alternatively activated macrophages(M2-type),which is beneficial for wound recovery.Based on these results observed in vitro,full-thickness skin wound experiments are conducted on rats,and the corresponding results show that MoS_(2)/Sericin under 808 nm irradiation exhibits the best performance in promoting wound healing.Overall,MoS_(2)-NS/Sericin exhibits a high potential for bacteria-infected wound healing.

关 键 词：MoS_(2) SERICIN Photothermal therapy ANTIBACTERIAL Infected wound healing 

分 类 号：TB383[一般工业技术—材料科学与工程]