Multidimensionally Nano‑topologized Polycaprolactone Fibrous Membrane Anchored with Bimetallic Peroxide Nanodots for Microenvironment‑Switched Treatment on Infected Diabetic Wounds  

作　　者：Lin Qi Yong Huang Zheng Liu Jiangshan Liu Jing Wang Huilun Xu Hao Yang Limin Liu Ganjun Feng Shuyu Zhang Yubao Li Li Zhang 

机构地区：[1]Analytical and Testing Center,Sichuan University,Chengdu 610065,China [2]Department of Orthopedic Surgery and Orthopedic Research Institute&West China Hospital,Sichuan University,Chengdu 610065,China [3]West China School of Basic Medical Science and Forensic Medicine,Sichuan University,Chengdu 610065,China

出　　处：《Advanced Fiber Materials》2024年第6期1777-1797,共21页先进纤维材料（英文）

基　　金：supported by the National Key Research and Development Program of China(2021YFA1201300);the Scientific Fund for Distinguished Young Scholars in Sichuan Province(2022JDJQ0051).

摘　　要：Delayed healing of diabetic wounds poses a major challenge to human health due to severe vascular dysfunction,sustained inflammation,and vulnerability to microbial infection.Herein,we constructed multidimensionally nano-topologized elec-trospun polycaprolactone(PCL)fibrous membranes with shish-kebab nanoarrays on each fiber through self-induced crys-tallization,on which the CuO2-MgO2 bimetallic peroxide nanodots(BPNs)were anchored by polydopamine(PDA)as the bridging layer.When activated by the acidic microenvironment(typically infected diabetic wound),BPNs on fibers reacted immediately to release Cu2+and Mg2+ions together with hydrogen peroxide(H2O2)molecules,which were then transferred into·OH radicals through Fenton-type reactions catalyzed by Cu2+for instant bacteria elimination.At the same time,the released Cu2+and Mg2+ions were retained to improve the angiogenesis and suppress the inflammation infiltration,thus remodeling the wound microenvironment.Meanwhile,the one-dimensional(1D)-constructed nano shish-kebabs and PDA coating on fibers provided additional topological activation for cell adhesion and directed migration along the aligned fiber orientation.Through the meticulous design,the resultant membranes markedly accelerated the infected wound healing in the diabetic rat model.This study pioneers a unique design to develop a nanocomposite fibrous membrane that combines multidimensional topologies with chemodynamic therapy(CDT),for efficiently combating infected diabetic wounds.

关 键 词：Electrospinning POLYCAPROLACTONE Multidimensional topology Metal peroxides Diabetic wound 

分 类 号：TB383[一般工业技术—材料科学与工程]