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作 者:Wen Liu Wei Zhao Kunrong Xie Xue Feng Li Yufu Wang Deyan Kong Yanju Liu Jinsong Leng
机构地区:[1]National Key Laboratory of Science and Technology On Advanced Composites in Special Environment,Harbin Institute of Technology,Harbin 150080,People’s Republic of China [2]Department of Astronautical Science and Mechanics,Harbin Institute of Technology(HIT),No.92 West Dazhi Street,P.O.Box 301,Harbin 150001,People’s Republic of China [3]Department of Orthopedic Surgery,Second Affiliated Hospital of Harbin Medical University,No.246,Baojian Road,Harbin 150086,People’s Republic of China [4]MIIT Key Laboratory of Critical Materials Technology for New Energy Conversion and Storage,School of Chemistry and Chemical Engineering,Harbin Institute of Technology,No.92,West Dazhi Street,Harbin 150001,People’s Republic of China
出 处:《Advanced Fiber Materials》2024年第6期1942-1954,共13页先进纤维材料(英文)
基 金:supported by the National Key R&D Program of China(No.2022YFB3805700);National Natural Science Foundation of China(No.92271206).
摘 要:Conventional wound dressings only protect passively against bacterial infection.Emerging mechanically active adhesive dressings(AADs)are inspired by the active closure of embryonic wounds.It can promote wound healing by actively con-tracting the wound bed.AADs meet the requirements of high toughness,stimulus-response,and dynamic adhesion proper-ties,which are challenging.Hence,we construct a water-responsive shape memory polyurea fibrous membrane(PU-fm)featuring favorable toughness,wet-adhesion,breathability,absorbency of four times its weight,and antibacterial.First,the water-toughened electrospun PU-fm is fabricated using a homemade polyurea(PU)elastomer with multistage hydrogen bond networks as a spinning solution.Furthermore,a Janus-structured polyurea-polydopamine-silver fibrous membrane(PU@PDA@Ag-fm)is engineered,integrating antibacterial properties without compromising mechanical robustness.It demonstrates strong adhesion to the skin,actively promotes wound contraction,and enables adaptive wrapping of tissues of varying sizes by the water-driven shape memory effect.Antibacterial tests and wound healing experiments indicate that the PU@PDA@Ag-fm has favorable antibacterial properties against Escherichia coli(E.coli)and accelerates the wound healing rate by 20%.For the first time,water-responsive shape memory PU-fm as the AADs is constructed,providing a new strategy for wound management.This can be extended to applications in other smart devices for biomedicine such as tendon repair,and bioelectronic interfaces.
关 键 词:Mechanically active dressing Electrospun fibrous membrane Janus structure Water-responsive shape memory
分 类 号:R318.08[医药卫生—生物医学工程]
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