Immobilization of a Metal-Organic Framework on a Nanofiber Membrane as Artificial Platelets for Efficient Hemostasis  

作　　者：Binglin Bie Zhanglong Zhu Yonggang Lv 

机构地区：[1]State Key Laboratory of New Textile Materials and Advanced Processing Technologies,Wuhan Textile University,Wuhan 430200,Hubei Province,China

出　　处：《Advanced Fiber Materials》2024年第5期1456-1469,共14页先进纤维材料（英文）

基　　金：supported by the National Natural Science Foundation of China(U23A2070 and 22201223);Chutian Scholar Foundation of Hubei Province and Natural Science Foundation of Hubei Province,China(2022CFA023).

摘　　要：Medical hemostatic gauze is one of the most common agents for bleeding management used in pre-hospital care and clinical treatment.An ideal hemostat requires the features including fast coagulation ability,high biocompatibility and low cost,which is difficult to be achieved simultaneously.Herein,we reported a chemical immobilization method to uniformly anchor the zeolitic imidazolate framework(ZIF-8)nanoparticles on polyvinyl alcohol(PVA)membrane,which dramatically accelerated the in vivo conversion process of prothrombin to thrombin,achieving a short hemostasis time around 60 s with a low amount of blood loss of 23 mg.Later,the hemostatic mechanism was unveiled by two pathways involving the activation of platelets and the conversion of prothrombin,indicating that this ZIF-8-based membrane works in a similar way to natural platelet-based physiological processes.More importantly,the convenient manufacturing and excellent biocompatibility of ZIF-8-based membrane provide a practical candidate hemostat for clinical bleeding management.

关 键 词：Noncompressible hemostasis Immobilization of metal-organic frameworks Artificial platelets Nanofiber membrane 

分 类 号：TB383[一般工业技术—材料科学与工程]