Fiber-Reinforced Silk Microneedle Patches for Improved Tissue Adhesion in Treating Diabetic Wound Infections  

作　　者：Yixin Wang Pengpeng Guan Ruiyi Tan Zhenghui Shi Qing Li Bitao Lu Enling Hu Weiwei Ding Wenyi Wang Bowen Cheng Guangqian Lan Fei Lu 

机构地区：[1]State Key Laboratory of Resource Insects,College of Sericulture,Textile and Biomass Sciences,Southwest University,Chongqing 400715,China [2]Chongqing Engineering Research Center of Biomaterial Fiber and Modern Textile,Chongqing 400715,China [3]Division of Trauma and Surgical Intensive Care Unit,Research Institute of General Surgery,Jinling Hospital,Medical School of Nanjing University,Nanjing 210002,Jiangsu Province,China [4]Department of Applied Biology and Chemical Technology,The Hong Kong Polytechnic University,Hung Hom,Hong Kong,China [5]School of Textile Science and Engineering,Tianjin Polytechnic University,Tianjin 300387,China

出　　处：《Advanced Fiber Materials》2024年第5期1596-1615,共20页先进纤维材料（英文）

基　　金：supported by the National Natural Science Foundation of China(No.51803171);the Fundamental Research Funds for Central Universities(No.SWU-XDPY22010).

摘　　要：Microneedles(MNs)with unique three-dimensional stereochemical structures are suitable candidates for tissue fixation and drug delivery.However,existing hydrogel MNs exhibit poor mechanical properties after swelling and require complex preparation procedures,impeding their practical application.Hence,we engineered chitosan fiber-reinforced silk fibroin MN patches containing epigallocatechin gallate(SCEMN).A formic acid-calcium chloride system was introduced to fabricate hydrogel MNs with excellent inherent adhesion,and the incorporation of chitosan fiber as a reinforcing material enhanced mechanical strength and viscosity,thereby increasing the physical interlocking with tissue and the ability to maintain shape.The SCEMN with a lower insertion force firmly adhered to porcine skin,with a maximum detachment force of 11.98 N/cm^(2).Additionally,SCEMN has excellent antioxidant and antibacterial properties,facilitates macrophage polarization from M1 to M2,and demonstrates superior performance in vivo for diabetic wound repair compared with the commercial product Tegaderm^(TM).This study represents the first trial of fiber-reinforced hydrogel MNs for robust tissue adhesion.Our findings underscore the significance of this innovative approach for advancing MN technology to enhance tissue adhesion and accel-erate wound healing.

关 键 词：Fibrous reinforcement Double-sided microneedle patch Swellable hydrogel Tissue adhesion 

分 类 号：R318[医药卫生—生物医学工程] TB383[医药卫生—基础医学]