益气抗萎汤对慢性萎缩性胃炎患者相关生长因子及胃肠激素的影响  

Influence of Yiqi Kangwei decoction on related growth factors and gastrointestinal hormones in patients with chronic atrophic gastritis

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作  者:黎锦沅 陈瑞年 赵雯文 郑佳连[3] LI Jin-yuan;CHEN Rui-nian;ZHAO Wen-wen;ZHENG Jia-lian(Department of Spleen and Stomach Diseases,Shenzhen Hospital of Integrated Traditional Chinese and Western Medicine,Shenzhen 518104;General Practice Center,Fuyong People's Hospital,Bao an,Shenzhen 518103,Guangdong;Department of Gastroenterology and Hepatology,Affiliated Hospital of Liaoning University of Traditional Chinese Medicine,Shenyang 110000,Liaoning,China)

机构地区:[1]深圳市中西医结合医院脾胃病科,广东深圳518104 [2]深圳市宝安区福永人民医院全科诊疗中心,广东深圳518103 [3]辽宁中医药大学附属医院消化肝病科,辽宁沈阳110000

出  处:《川北医学院学报》2024年第12期1612-1615,共4页Journal of North Sichuan Medical College

基  金:辽宁省科学技术计划项目(2019-MS-231)。

摘  要:目的:探究益气抗萎汤对慢性萎缩性胃炎(CAG)患者相关生长因子及胃肠激素的影响。方法:将106例CAG(脾胃虚弱证)患者,按不同治疗方法分为常治组(n=53)和中西组(n=53)。常治组行西医疗法;中西组在常治组基础上加用益气抗萎汤治疗。两组患者均治疗两个月。评价两组患者中医证候总分及减少率,对比两组患者给药前后相关生长因子及其胃肠激素的差异。结果:给药8周后,中西组总有效率为96.23%,高于常治组的81.13%(P<0.05);两组患者中医症候积分、转化生长因子及胃泌素释放量均较给药前减少(P<0.05),且中西组以上指标均低于常治组(P<0.05);两组血管通透因子、胃动素及生长抑素水平均增加(P<0.05),且中西组高于常治组(P<0.05)。结论:益气抗萎汤用于治疗CAG(脾胃虚弱证)患者疗效佳,能明显改善中医证候评分,对相关生长因子和胃肠激素有积极作用。Objective:To explore the influence of Yiqi Kangwei decoction on related growth factors and gastrointestinal hormones in patients with chronic atrophic gastritis(CAG).Methods:106 patients with CAG(spleen-stomach deficiency syndrome)were divided into conventional treatment group(n=53)and Chinese-Western group(n=53)according to different treatment methods.The conventional treatment group was treated with western medicine,while the study group Chinese-Western group was added with Yiqi Kangwei decoction.Both groups were treated for 2 months.The total score and reduction rates of TCM syndromes were assessed in both groups,and the differences in related growth factors and gastrointestinal hormones before and after medication were compared between both groups.Results:After 8 weeks of medication,the total effective rate with 96.23%in Chinese-Western group was higher than 81.13%in conventional treatment group(P<0.05).The scores of TCM symptoms,transforming growth factor and gastrin release volume were declined in the two groups(P<0.05),and the above indicators were lower in Chinese-Western group than those in conventional treatment group(P<0.05).The levels of vascular permeability factor,motilin and somatostatin in both groups were increased after 8 weeks of medication(P<0.05),and the Chinese-Western group was higher than the conventional group(P<0.05).Conclusion:Yiqi Kangwei decoction has good efficacy on patients with CAG(spleen-stomach deficiency syndrome),and can significantly improve TCM syndromes scores,and it has a positive effect on related growth factors and gastrointestinal hormones.

关 键 词:慢性萎缩性胃炎 益气抗萎汤 脾胃虚弱证 生长因子 胃肠激素 

分 类 号:R278[医药卫生—中医学]

 

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