喂养不耐受早产儿肠道菌群、血管活性肠肽、胃泌素及胃动素水平与喂养不耐受的相关性分析  

Correlation analysis of intestinal microbiota,vasoactive intestinal peptide,gastrin and motilin levels with feeding intolerance in preterm infants with feeding intolerance

作　　者：刘诗芳[1] 吴丙美 赵怡然 LIU Shi-fang;WU Bing-mei;ZHAO Yi-ran(Department of Public Health,Tangshan 063001,Hebei,China;Department of Pediatrics,Tangshan People's Hospital,Tangshan 063001,Hebei,China;Department of Pediatrics,Tangshan Maternal and Children Health Hospital,Tangshan 063001,Hebei,China)

机构地区：[1]唐山市人民医院,公共卫生科,河北唐山063001 [2]唐山市人民医院,儿科,河北唐山063001 [3]唐山市妇幼保健院儿科,河北唐山063001

出　　处：《川北医学院学报》2024年第12期1624-1627,共4页Journal of North Sichuan Medical College

基　　金：河北省医学科学研究重点项目(20181319)。

摘　　要：目的:分析喂养不耐受早产儿肠道菌群、血管活性肠肽(VIP)、胃泌素(GAS)及胃动素(MOT)与喂养不耐受的相关性。方法:回顾性分析82例早产儿的临床资料,根据早产儿是否发生喂养不耐受分为不耐组(n=31)与对照组(n=51)。收集其相关资料进行比较,采用Pearson相关性分析早产儿肠道菌群、VIP、GAS及MOT水平变化与喂养不耐受的关系。结果:出生7 d时,不耐组早产儿肠道双歧杆菌、乳杆菌水平低于对照组(P<0.05);不耐组肠道双歧杆菌、乳杆菌水平增加量低于对照组(P<0.05);不耐组早产儿VIP、GAS及MOT水平低于对照组(P<0.05);不耐组早产儿VIP、GAS及MOT增加量低于对照组(P<0.05);经Pearson相关性分析显示,早产儿喂养不耐受与其双歧杆菌、乳杆菌及VIP、GAS、MOT增长水平负相关(P<0.05)。结论:早产儿肠道菌群、VIP、GAS及MOT低水平与喂养不耐受密切相关,可通过检测上述指标水平实施干预措施。Objective:To analyze the correlation between intestinal microbiota,vasoactive intestinal peptide(VIP),gastrin(GAS)and motilin(MOT)and feeding intolerance in preterm infants with feeding intolerance.Methods:The clinical data of 82 premature infants born were collected retrospectively.The premature infants were divided into intolerance group(n=31)and control group(n=51)according to the presence or absence of feeding intolerance.Their basic information was collected through questionnaire survey.Pearson correlation analysis was conducted to explore the relationship between changes in gut microbiota,VIP,GAS and MOT levels and feeding intolerance in premature infants.Results:On 7 day after birth,the levels of bifidobacteria and lactobacilli in the intolerance group were lower than those in the control group(P<0.05).Meanwhile,the growth levels of intestinal bifidobacteria and lactobacillus in the intolerant group were lower than those in the control group(P<0.05).On 7 day after birth,the levels of VIP,GAS and MOT in the intolerance group were lower than those in the control group(P<0.05).The growth levels of VIP,GAS and MOT in the intolerant group were lower than those in the control group(P<0.05).Pearson correlation analysis found that feeding intolerance in premature infants was negatively correlated with the increases in bifidobacteria,lactobacilli,VIP,GAS and MOT(P<0.05).Conclusion:Low levels of gut microbiota,VIP,GAS and MOT in premature infants are closely related to feeding intolerance.Intervention measures can be taken after detecting the levels of these indicators.

关 键 词：早产儿 喂养不耐受 肠道菌群 血管活性肠肽 胃泌素 胃动素 

分 类 号：R722.6[医药卫生—儿科]