屈螺酮炔雌醇片Ⅱ联合奥利司他对肥胖型多囊卵巢综合征患者糖脂代谢、胰岛素抵抗和血清脂肪因子水平的影响  

Effects of drospirenone ethinyl estradiol tablets Ⅱ combined with orlistat on glucose and lipid metabolism,insulin resistance and serum adipocytokine levels in obese PCOS patients

作　　者：李蕊 冯玉军 张华俊 王岩岩 艾敬 李昕岳 LI Rui;FENG Yu-jun;ZHANG Hua-jun;WANG Yan-yan;AI Jing;LI Xin-yue(Department of Gynecology,Qinhuangdao 066000,Hebei,China;Department of Pharmacy,Qinhuangdao Maternal and Child Health Hospital,Qinhuangdao 066000,Hebei,China;Department of Pharmacy,Peking University Third Hospital Qinhuangdao Hospital,Qinhuangdao 066000,Hebei,China)

机构地区：[1]秦皇岛市妇幼保健院,妇科,河北秦皇岛066000 [2]秦皇岛市妇幼保健院,药剂科,河北秦皇岛066000 [3]北京大学第三医院秦皇岛医院药剂科,河北秦皇岛066000

出　　处：《川北医学院学报》2024年第12期1632-1635,1644,共5页Journal of North Sichuan Medical College

基　　金：河北省卫生健康委员会项目(20221621)。

摘　　要：目的:探讨屈螺酮炔雌醇片Ⅱ联用奥利司他治疗肥胖型多囊卵巢综合征(PCOS)患者的疗效。方法:纳入110例肥胖型PCOS患者作为研究对象,将患者按治疗方式不同分为对照组与观察组,每组各55例。对照组予以屈螺酮炔雌醇片Ⅱ治疗;观察组予以屈螺酮炔雌醇片Ⅱ联用奥利司他治疗,两组均治疗3个月。于治疗前后对比两组生殖内分泌指标、身体测量参数[体质量指数(BMI)、腰臀比(WHR)]、血脂水平、空腹血糖(FPG)、空腹胰岛素(FINS)、胰岛素抵抗指数(HOMA-IR)及脂联素、抵抗素水平;并记录两组疗效和不良反应发生情况。结果:观察组患者临床总有效率(90.91%)显著高于对照组(74.55%)(P<0.05)。治疗后,观察组患者血清睾酮、BMI、甘油三酯、低密度脂蛋白胆固醇、FPG、FINS、HOMA-IR、抵抗素水平均显著低于对照组(P<0.05);血清脂联素水平显著高于对照组(P<0.05)。两组患者不良反应总发生率无统计学差异(P>0.05)。结论:屈螺酮炔雌醇片Ⅱ联用奥利司他能够有效降低患者血清T水平,改善糖脂代谢、胰岛素抵抗,调节血清脂肪因子水平,有较好疗效。Objective:To investigate the efficacy of drospirenone ethinyl estradiol tablets Ⅱ combined with orlistat in the treatment of patients with obese polycystic ovary syndrome(PCOS).Methods:A total of 110 patients with obese PCOS were included in the study.The patients were divided into control group and observation group according to different treament methods,with 55 cases in each group.The control group was treated with drospirenone ethinylestradiol tablets Ⅱ,and the observation group was treated with drospirenone ethinylestradiol tablets Ⅱ combined with orlistat.Both groups were treated for 3 months.Before and after treatment,the reproductive endocrine indexes,body measurement parameters[body mass index(BMI),waist-to-hip ratio(WHR)],blood lipid levels,fasting blood glucose(FPG),insulin resistance index(HOMA-IR),serum adiponectin and resistin levels were compared between the two groups.The efficacy and adverse reactions were compared between the two groups.Results:The total effective rate of the observation group(90.91%)was higher than that of the control group(74.55%)(P<0.05).After treatment,the levels of serum testosterone,BMI,triglyceride,low density lipoprotein cholesterol,FPG,FINS,HOMA-IR and resistin levels in the observation group were lower than those in the control group(P<0.05).The levels of serum adiponectin in the observation group was higher than that in the control group(P<0.05).There was no statistically significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion:Drospirenone ethiny lestradiol tablets Ⅱ combined with orlistat can effectively reduce the serum T level of patients,improve glucose and lipid metabolism,insulin resistance,regulate the level of serum adipocytokines,and have good therapeutic effects.

关 键 词：多囊卵巢综合征 奥利司他 屈螺酮炔雌醇片Ⅱ 糖脂代谢 胰岛素抵抗 脂肪细胞因子 

分 类 号：R588.6[医药卫生—内分泌]