骨化三醇联合经皮椎体后凸成形术治疗脊柱脆性骨折的临床疗效  

Clinical efficacy of calcitriol in the treatment of brittle fractures after percutaneous vertebral plasty was analyzed

作　　者：缪青 陈静[1] 陶峰琴[2] 诸葛恒艳[1] MIAO Qing;CHEN Jing;TAO Feng-qin;ZHUGE Heng-yan(Department of OrthopaedicsⅡ;Department of OrthopedicsⅠ,No.904 Hospital of the Joint Logistic Support Force of the Chinese People's Liberation Army,Wuxi 214000,Jiangsu,China)

机构地区：[1]中国人民解放军联勤保障部队第904医院,骨科二区,江苏无锡214000 [2]中国人民解放军联勤保障部队第904医院,骨科一区,江苏无锡214000

出　　处：《川北医学院学报》2024年第12期1664-1667,1675,共5页Journal of North Sichuan Medical College

基　　金：江苏省无锡市科协软科学研究项目(KX-23-C092)。

摘　　要：目的:探究骨化三醇联合经皮椎体后凸成形术(PKP)治疗脊柱脆性骨折的临床疗效。方法:将95例脊柱脆性骨折患者,根据干预方式不同分为对照组(n=48)和研究组(n=47)。对照组行PKP治疗;研究组实施骨化三醇联合PKP治疗,两组均治疗3个月。比较两组患者骨性愈合时间、住院时间、术后24 h及3个月的血清骨钙素(BGP)、降钙素(hCT)及碱性磷酸酶(ALP)、血小板衍生生长因子(PDGF)、可溶性细胞间粘附分子1(sICAM-1)、可溶性血管细胞粘附分子1(sVCAM-1)水平、骨折愈合优良率及并发症发生率。结果:研究组患者骨性愈合时间、住院时间均短于对照组(P<0.05);术后3个月,两组患者血清BGP、hCT、ALP水平均较术后24 h增高(P<0.05),且研究组高于对照组(P<0.05);两组患者血清PDGF、sICAM-1、sVCAM-1水平均较术后24 h改善,且研究组较对照组患者改善更佳(P<0.05);研究组治疗优良率为89.36%,高于对照组的60.42%(P<0.05);研究组并发症发生率为6.39%,低于对照组的22.92%(P<0.05)。结论:脊柱脆性骨折患者应用骨化三醇联合PKP治疗整体效果佳,不仅能促进骨愈合,还能促进骨重建,增强骨稳定性,降低并发症发生率,优势明显。Objective:To investigate the clinical efficacy of combining calcitriol with percutaneous kyphoplasty(PKP)for the treatment of spinal fragility fractures.Methods:The 95 patients with brittle fractures were divided into two groups by different intervention methods:the control group(n=48)and the treatment group(n=47).The control group received PKP as a treatment,while the treatment group underwent joint calcitriol PKP.Both groups were treated for a duration of 3 months.The bone healing time,hospital stay,serum levels of osteocalcin(BGP),calcitonin(hCT),alkaline phosphatase(ALP),platelet-derived growth factor(PDGF),soluble intercellular adhesion molecule-1(sICAM-1),soluble vascular cell adhesion molecule-1(sVCAM-1)and bone were compared between the two groups at 24 hours and 3 months post-operation.Additionally,the excellent rate of fracture healing and the incidence of complications were evaluated.Results:The treatment group exhibited significantly shorter bone healing time and hospitalization time compared to the control group(P<0.05).The serum levels of BGP,hCT,and ALP in both groups were elevated at 3 months post-operation compared to 24 hours post-operation.Furthermore,the treatment group exhibited higher levels than the control group(P<0.05).The serum levels of PDGF,sICAM-1,and sVCAM-1 in both groups showed significant improvement at 3 months post-operation compared to the levels observed at 24 hours post-operation.Furthermore,the treatment group exhibited a superior level of improvement compared to the control group(P<0.05).After 3 months of treatment,the treatment group demonstrated a significantly higher rate of excellence and proficiency at 89.36%,surpassing the control group s rate of 60.42%(P<0.05).After 3 months of treatment,the team the incidence of complications was 6.39%,which was lower than the control group 22.92%(P<0.05).Conclusion:The use of calcitriol in patients with brittle fractures undergoing joint PKP has shown overall positive effects.It not only promotes bone healing but also facilitates b

关 键 词：骨化三醇 经皮椎体后凸成形术 脊柱脆性骨折 骨愈合 骨重建 并发症 

分 类 号：R681.5[医药卫生—骨科学]