Bidirectional associations among gallstone disease,non-alcoholic fatty liver disease,kidney stone disease  

作　　者：Guo-Heng Jiang Sheng Li Hong-Yu Li Lin-Jun Xie Shi-Yi Li Zi-Tong Yan Wen-Qian Yu Jing Luo Xuan Bai Ling-Xi Kong Yan-Mei Lou Chi Zhang Guang-Can Li Xue-Feng Shan Min Mao Xin Wang 

机构地区：[1]Department of Epidemiology and Biostatistics,West China School of Public Health and West China Fourth Hospital,Sichuan University,Chengdu 610041,Sichuan Province,China [2]Department of Pharmacy,The First Affiliated Hospital of Chongqing Medical University,Chongqing 400016,China [3]Department of Health Management,Beijing Xiaotangshan Hospital,Beijing 102211,China [4]Department of Prevention,Tianjin Medical University Cancer Institute and Hospital,Tianjin 300060,China [5]Department of Pharmacy,The People’s Hospital of Kaizhou District,Chongqing 405400,China [6]Department of Pharmacy,Bishan Hospital of Chongqing Medical University,Chongqing 402760,China [7]Department of Pediatric Pulmonology and Immunology,West China Second University Hospital,Sichuan University,Chengdu 610041,Sichuan Province,China

出　　处：《World Journal of Gastroenterology》2024年第46期4914-4928,共15页世界胃肠病学杂志（英文）

基　　金：Supported by National Natural Science Foundation of China,No.81802508 and No.81903398;Chongqing Natural Science Foundation Program,No.CSTC2019JCYJ-MSXMX0466 and No.CSTB2022NSCQ-MSX0206;The Research Start-up Fund for Introduction of Talents of Sichuan University,No.YJ2021112;Medical Youth Innovation Research Project of Sichuan Province,No.Q21016;Natural Science Foundation of Sichuan,No.2023NSFSC1927;Sichuan Province Central Government Guide Local Science and Technology Development Project,No.2023ZYD0097;"From 0 to 1"Innovation Project of Sichuan University,No.2023SCUH0026.

摘　　要：BACKGROUND A body of evidence has suggested bidirectional relationships among gallstone disease(GSD),non-alcoholic fatty liver disease(NAFLD),and kidney stone disease(KSD).However,the results are inconsistent,and studies on this topic in China are relatively few.Our goal is to explore the bidirectional associations among these three diseases through a multicenter study,systematic review,and meta-analysis.AIM To explore the bidirectional associations among these three diseases through a multicenter study,systematic review,and meta-analysis.The results may help to investigate the etiology of these diseases and shed light on the individualized prevention of these three diseases.METHODS Subjects who participated in physical examinations in Beijing,Tianjin,Chongqing in China were recruited.Multivariable logistic regression was employed to explore the bidirectional relationships among GSD,KSD,and NAFLD.Systematic review and meta-analysis were initiated to confirm the epidemiologic evidence from previous observational studies.Furthermore,trial sequential analysis(TSA)was conducted to evaluate whether the evidence was sufficient and conclusive.RESULTS Significant bidirectional associations were detected among the three diseases,independent of potential confounding factors.The pooled results of the systematic review and meta-analysis also corroborated the aforementioned results.The combined evidence from the multicenter study and meta-analysis was significant[pooled odds ratio(OR)=1.42,95%CI:1.16-1.75,KSD→GSD;pooled OR=1.48,95%CI:1.31-1.67,GSD→KSD;pooled OR=1.31,95%CI:1.17-1.47,GSD→NAFLD;pooled OR=1.37,95%CI:1.26-1.50,NAFLD→GSD;pooled OR=1.28,95%CI:1.08-1.51,NAFLD→KSD;pooled OR=1.21,95%CI:1.16-1.25,KSD→NAFLD].TSA indicated that the evidence was sufficient and conclusive.CONCLUSION The present study presents relatively sufficient evidence for the positive bidirectional associations among GSD,KSD,and NAFLD.The results may provide clues for investigating the etiology of these three diseases and offer a guideline

关 键 词：GALLSTONES Non-alcoholic fatty liver disease Kidney calculi Cross-sectional study META-ANALYSIS 

分 类 号：R725.7[医药卫生—儿科] R726.9[医药卫生—临床医学]