Nicorandil as a promising therapeutic option for ventricular arrhythmia:A case report and review of literature  

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作  者:Ling-Yu Bai Ming Zhao Kui-Ying Ma 

机构地区:[1]Department of Cardiovascular Medicine,Affiliated Hospital of Inner Mongolia University for Nationalities,Tongliao 028000,Inner Mongolia Autonomous Region,China

出  处:《World Journal of Cardiology》2024年第12期768-775,共8页世界心脏病学杂志(英文)

摘  要:BACKGROUND Ventricular arrhythmia is a common type of arrhythmia observed in clinical practice.It is primarily characterized by premature ventricular contractions,ventricular tachycardia,and ventricular fibrillation.Abnormal formation or transmission of cardiac electrical impulses in patients affects cardiac ejection function.It may present with symptoms such as palpitations,dyspnea,chest discomfort,and reduced exercise tolerance.In severe cases,ventricular arrhy-thmia can even lead to death.Therefore,prompt treatment is very much essential upon diagnosis.The symptoms did not improve after previous conventional drugs and electrical defibrillation treatment,but the ventricular arrhythmia was prevented after the addition of nicorandil.CASE SUMMARY A 75-year-old female patient was admitted to the hospital because of intermittent chest tightness,shortness of breath for 10 days,and fainting once for 7 days.Combined with laboratory tests and auxiliary examination,the patient was tentatively diagnosed with coronary heart disease or arrhythmia-atrial fibrillation.After admission,the patient had intermittent ventricular arrhythmia,which was uncontrolled with lidocaine,defibrillation,and amiodarone.However,when she was treated with nicorandil,the ventricular arrhythmia stopped.Nicorandil mitigates the action potential duration by facilitating the opening of potassium ion channels,thereby regulating the likelihood of premature and delayed depolar-ization in two distinct phases and subsequently averting the onset of malignant ventricular arrhythmia.Nicorandil may inhibit ventricular arrhythmia by dilating coronary arteries,improving coronary microcirculation and reducing myocardial fibrosis.CONCLUSION option for inhibiting ventricular arrhythmias.

关 键 词:NICORANDIL Ventricular arrhythmia Electrical storm Phase 2 early after-depolarization AMIODARONE MICROCIRCULATION Myocardial fibrosis LIDOCAINE Case report 

分 类 号:R542.21[医药卫生—心血管疾病]

 

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