Efficacy and safety of Tripterygium wilfordii glycosides tablets combined with Western medicine for patients with rheumatic immune diseases  

作　　者：Hang Shu Xiao-Yu Chen Jie Zhao Pin Li Zhen Sun 

机构地区：[1]Department of Traditional Chinese Medicine,Hangzhou Special Service Recuperation Center of Chinese People's Liberation Army Air Force,Nanjing 210000,Jiangsu Province,China [2]Department of Convalescence,Hangzhou Special Service Recuperation Center of Chinese People's Liberation Army Air Force,Nanjing 210000,Jiangsu Province,China

出　　处：《World Journal of Clinical Cases》2025年第6期14-23,共10页世界临床病例杂志（英文）

摘　　要：BACKGROUND Rheumatic immune diseases are a group of chronic inflammatory diseases charac-terized by joint and systemic multi-organ involvement,including rheumatoid arthritis,systemic lupus erythematosus,and Sjogren’s syndrome,among others.The pathogenesis of these diseases is related to the abnormal activation and regulatory imbalance of the immune system.The prevalence and morbidity of rheumatic immune diseases are high,imposing a significant burden on patients'quality of life and socio-economic costs.Currently,the treatment of rheumatic immune diseases mainly relies on Western medicine,such as non-steroidal anti-inflammatory drugs,glucocorticoids,disease-modifying antirheumatic drugs,and biologics.However,the therapeutic effects of Western medicine are not ideal,some patients poorly respond or are resistant to Western medicine,and long-term use often causes various adverse reactions.AIM To systematically evaluate the efficacy and safety of Tripterygium wilfordii gly-cosides tablets combined with Western medicine in the treatment of patients with rheumatic immune diseases.METHODS This study conducted a meta-analysis to systematically evaluate the efficacy and safety of Tripterygium wilfordii glycosides tablets combined with Western medicine for patients with rheumatic immune diseases.Chinese and English databases were searched for randomized controlled trials(RCTs)on the treatment of rheumatic immune diseases with Tripterygium wilfordii glycosides tablets combined with Western medicine.The quality of the included studies was assessed using the Cochrane risk of bias assessment tool.Meta-analysis was performed using RevMan 5.4 software.RESULTS The meta-analysis included 11 RCTs involving 1026 patients with rheumatic immune diseases.The combined treatment significantly reduced the risk of disease recurrence(relative risk=1.07,95%confidence interval:1.01-1.15,P<0.05)and showed no significant heterogeneity(I2=0%,P=0.53),indicating that Tripterygium wilfordii glycosides tablets combined with Western medicine is an e

关 键 词：Rheumatic immune diseases Tripterygium wilfordii polyglycosides tablets Western medicine treatment Systematic review META-ANALYSIS 

分 类 号：R593.2[医药卫生—内科学] R541.75[医药卫生—临床医学]