Ultrasound features of congenital cytomegalovirus infection in the first trimester:A case report  

作　　者：Xiao-Li Chen Li-Qiang Zhang Li-Li Bai 

机构地区：[1]Department of Ultrasound,Wenzhou Central Hospital,Wenzhou 325000,Zhejiang Province,China

出　　处：《World Journal of Clinical Cases》2025年第5期30-35,共6页世界临床病例杂志（英文）

摘　　要：BACKGROUND Congenital cytomegalovirus(CMV)infection represents a significant public health concern as the most prevalent viral infection in newborns,potentially leading to severe neurological and developmental complications.The majority of cases are asymptomatic and remain undetected during pregnancy due to the absence of effective screening methods.CASE SUMMARY A 27-year-old primigravida presented for early pregnancy ultrasound,which revealed an atypical finding:A normal anechoic thalamus appearing hyperechoic on the mid-sagittal view of the fetal head.Subsequent ultrasound examinations during mid and late gestation demonstrated classic intracranial features sug-gestive of congenital CMV infection.Chromosomal karyotyping and microarray analysis of the fetus yielded no significant abnormalities.Following compre-hensive prenatal counseling regarding potential adverse fetal outcomes,the patient elected to continue her pregnancy.She ultimately underwent cesarean delivery at 42 weeks gestation at another facility,resulting in the birth of a female neonate.At five months of age,the infant presented with epilepsy and significant growth and developmental delays.CONCLUSION Congenital CMV infection occurs during the first trimester may manifest as hyperechoic thalamus which can be revealed by ultrasound in the mid-saggital view of the fetal head.Future research should investigate the correlation between echogenic thalamus and developmental outcomes,as well as explore early sc-reening techniques for suspected congenital CMV infection cases.

关 键 词：Prenatal diagnosis Congenital infection CYTOMEGALOVIRUS Fetal ultrasound Case report 

分 类 号：R714.258[医药卫生—妇产科学]