Intersection of the glymphatic system and diabetes: Navigating a new frontier  

作　　者：Asad Gul Rao Abdulqadir J Nashwan 

机构地区：[1]Clinical Medicine,Dow Medical College,Karachi 74200,Pakistan [2]Department of Nursing and Midwifery Research,Hamad Medical Corporation,Doha 3050,Qatar

出　　处：《World Journal of Diabetes》2024年第12期2376-2379,共4页世界糖尿病杂志（英文）

摘　　要：Diabetes is one of the most devastating medical dilemmas impacting every region of the world severely.The study by Tian et al investigates glymphatic system dys-function in the context of glucose metabolism and diabetes,using diffusion tensor imaging along the perivascular space.The study evaluated individuals with type 2 diabetes mellitus(T2DM),prediabetes,and normal glucose metabolism.It found that prediabetic and T2DM groups had significantly impaired glymphatic func-tion.Glymphatic dysfunction may serve as an early indicator of cognitive deteri-oration in diabetes due to the correlations shown between these abnormalities and clinical factors as well as cognitive performance.The study has some positives,such as thorough evaluations and novel imaging methods,but its cross-sectional design and limited sample size restrict its applicability.More extensive,long-term research is required to verify these results.Furthermore,there are significant cli-nical implications.Patients with diabetes may benefit from immediate therapies to prevent microvascular and macrovascular damage if glymphatic dysfunction is identified early.The study promotes comprehensive diabetes care with a focus on maintaining cognitive function.In conclusion,the work of Tian et al is crucial because it opens the door to better treatment and diagnostic strategies for dia-betes-related cognitive deterioration.

关 键 词：Glymphatic system Diabetes mellitus PREDIABETES Cognitive decline Diabetic brain damage 

分 类 号：R587.1[医药卫生—内分泌]