Psycho-gastroenterological profile of an Italian population of children with disorders of gut-brain interaction:A case-control study  

作　　者：Valentina Giorgio Ilaria Venezia Licia Pensabene Elisa Blasi Donato Rigante Paolo Mariotti Giuseppe Stella Gaia Margiotta Giovanna Quatrale Giuseppe Marano Marianna Mazza Antonio Gasbarrini Eleonora Gaetani 

机构地区：[1]Pediatric Unit,Department of Women,Children and Public Health Sciences,Fondazione Policlinico Universitario“A.Gemelli”IRCCS,UniversitàCattolica del Sacro Cuore,Rome 00168,Italy [2]Child Neuropsychiatry Unit,ASST Santi Paolo e Carlo,San Paolo Hospital,Milan 20142,Italy [3]Child Neuropsychiatry Unit,Department of Women,Children and Public Health Sciences,Fondazione Policlinico Universitario“A.Gemelli”IRCCS,UniversitàCattolica del Sacro Cuore,Rome 00168,Italy [4]Department of Medical and Surgical Sciences,Pediatric Unit,University Magna Graecia,Catanzaro 88100,Italy [5]Unit of Psychiatry,Fondazione Policlinico Universitario“A.Gemelli”IRCCS,Rome 00168,Italy [6]Department of Neurosciences,UniversitàCattolica del Sacro Cuore,Rome 00168,Italy [7]Department of Internal Medicine and Gastroenterology,Fondazione Policlinico Universitario"A.Gemelli"IRCCS,Rome 00168,Italy [8]Department of Medical and Surgical Sciences,Fondazione Policlinico Universitario"A.Gemelli"IRCCS,UniversitàCattolica del Sacro Cuore,Rome 00168,Italy

出　　处：《World Journal of Clinical Pediatrics》2025年第1期69-77,共9页世界临床儿科杂志（英文）

摘　　要：BACKGROUND Disorders of gut-brain interaction(DGBI)are common,but knowledge about their physiopathology is still poor,nor valid tools have been used to evaluate them in childhood.AIM To develop a psycho-gastroenterological questionnaire(PGQ)to assess the psycho-gastroenterological profile and social characteristics of a pediatric population with and without DGBI.METHODS One hundred and nineteen Italian children(age 11-18)were included:28 outpatient patients with DGBI(Rome IV criteria)and 91 healthy controls.They filled the PGQ,faces pain scale revised(FPS-R),Bristol stool chart,ga-strointestinal symptoms rating scale,state-trait anxiety inventory,Toronto alexithymia scale 20,perceived self-efficacy in the management of negative emotions and expression of positive emotions(APEN-G,APEP-G),irritable bowel syndrome-quality of life questionnaire,school performances,tobacco use,early life events,degree of digital-ization.RESULTS Compared to controls,patients had more medical examinations(35%of them went to the doctor more than five times),a higher school performance(23%vs 13%,P<0.05),didn’t use tobacco(never vs 16%,P<0.05),had early life events(28%vs 1%P<0.05)and a higher percentage of pain classified as 4 in the FPS-R during the examination(14%vs 7%,P<0.05).CONCLUSION Pediatric outpatients with DGBI had a higher prevalence of early life events,a lower quality of life,more medical examinations rising health care costs,lower anxiety levels.

关 键 词：Disorders of gut-brain interaction Functional gastrointestinal disorders Psycho-gastroenterological profile Gut-brain axis Rome IV criteria Pediatric patients 

分 类 号：R725.4[医药卫生—儿科]