Diabetes-inducing effects of bronchial asthma  

作　　者：Mohammed Al-Beltagi Adel Salah Bediwy Nermin Kamal Saeed Hosameldin A Bediwy Reem Elbeltagi 

机构地区：[1]Department of Pediatric,Faculty of Medicine,Tanta University,Tanta 31511,Alghrabia,Egypt [2]Department of Pediatric,University Medical Center,King Abdulla Medical City,Arabian Gulf University,Manama 26671,Manama,Bahrain [3]Department of Pulmonology,Faculty of Medicine,Tanta University,Tanta 31527,Alghrabia,Egypt [4]Department of Pulmonology,University Medical Center,King Abdulla Medical City,Arabian Gulf University,Manama 26671,Manama,Bahrain [5]Medical Microbiology Section,Department of Pathology,Salmaniya Medical Complex,Ministry of Health,Kingdom of Bahrain,Manama 26671,Manama,Bahrain [6]Medical Microbiology Section,Department of Pathology,Irish Royal College of Surgeon,Busaiteen 15503,Muharraq,Bahrain [7]Faculty of Medicine,Tanta University,Tanta 31527,Algharbia,Egypt [8]Department of Medicine,The Royal College of Surgeons in Ireland-Bahrain,Busiateen 15503,Muharraq,Bahrain

出　　处：《World Journal of Diabetes》2025年第1期121-139,共19页世界糖尿病杂志（英文）

摘　　要：BACKGROUND The relationship between diabetes mellitus(DM)and asthma is complex and can impact disease trajectories.AIM To explore the bidirectional influences between the two conditions on clinical outcomes and disease control.METHODS We systematically reviewed the literature on the relationship between DM and asthma,focusing on their impacts,mechanisms,and therapeutic implications.Various studies were assessed,which investigated the effect of glycemic control on asthma outcomes,lung function,and exacerbations.The study highlighted the role of specific diabetes medications in managing asthma.RESULTS The results showed that poor glycemic control in diabetes can exacerbate asthma,increase hospitalizations,and reduce lung function.Conversely,severe asthma,especially in obese individuals,can complicate diabetes management and make glycemic control more difficult.The diabetes-associated mechanisms,such as inflammation,microangiopathy,and oxidative stress,can exacerbate asthma and decrease lung function.Some diabetes medications exhibit anti-inflammatory effects that show promise in mitigating asthma exacerbations.CONCLUSION The complex interrelationship between diabetes and asthma suggests bidirectional influences that affect disease course and outcomes.Inflammation and microvascular complications associated with diabetes may worsen asthma outcomes,while asthma severity,especially in obese individuals,complicates diabetes control.However,the current research has limitations,and more diverse longitudinal studies are required to establish causal relationships and identify effective treatment strategies for individuals with both conditions.

关 键 词：Diabetes mellitus Bronchial asthma Glycemic control Lung function Asthma exacerbation Disease interaction MICROANGIOPATHY 

分 类 号：R587.1[医药卫生—内分泌]