Traditional Chinese medicine in the treatment of Helicobacter pylorirelated gastritis:The mechanisms of signalling pathway regulations  

作　　者：Pei-Pei Zhang Liang Li Hao-Yu Qu Guang-Yu Chen Meng-Zhou Xie Yan-Kun Chen 

机构地区：[1]School of Traditional Chinese Medicine,Hunan University of Chinese Medicine,Changsha 410200,Hunan Province,China [2]Hunan Engineering Technology Research Center for Medicinal and Functional Food,Hunan University of Chinese Medicine,Changsha 410200,Hunan Province,China [3]Key Laboratory of Traditional Chinese Medicine Heart and Lung Syndrome Differentiation and Medicated Diet and Dietotherapy,Hunan University of Chinese Medicine,Changsha 410200,Hunan Province,China [4]School of Informatics,Hunan University of Chinese Medicine,Changsha 410208,Hunan Province,China [5]Precision Medicine Research and Development Center,Zhuhai Institute of Advanced Technology,Chinese Academy of Sciences,Zhuhai 519000,Guangdong Province,China

出　　处：《World Journal of Gastroenterology》2025年第3期11-28,共18页世界胃肠病学杂志（英文）

基　　金：Supported by National Natural Science Foundation of China,No.82374323;and Hunan Graduate Research Innovation Project,No.2023CX15.

摘　　要：Helicobacter pylori-associated gastritis(HPAG)is a common condition of the gastrointestinal tract.However,extensive and long-term antibiotic use has resulted in numerous adverse effects,including increased resistance,gastrointestinal dysfunction,and increased recurrence rates.When these concerns develop,traditional Chinese medicine(TCM)may have advantages.TCM is based on the concept of completeness and aims to eliminate pathogens and strengthen the body.It has the potential to prevent this condition while also boosting the rate of Helicobacter pylori eradication.This review elaborates on the mechanism of TCM treatment for HPAG based on cellular signalling pathways,which reflects the flexibility of TCM in treating diseases and the advantages of multi-level,multipathway,and multi-target treatments for HPAG.

关 键 词：Helicobacter pylori Helicobacter pylori-associated gastritis Traditional Chinese medicine Signalling pathway Eliminate pathogens Strengthen the body 

分 类 号：R259[医药卫生—中西医结合]