Evaluation of autoimmune phenomena in patients with nonalcoholic fatty liver disease on the basis of liver pathology  

作　　者：Yu-Jin Zhu Yan Zhang Yao Rao Yong Jiang Yong-Gang Liu Jian-Zhou Li Jia-Qi Yuan Ying Zhao Wen-Wen Zheng Lin Ma Chun-Yan Wang Jia Li 

机构地区：[1]Department of Infectious Diseases,Xi’an No.3 Hospital,the Affiliated Hospital of Northwest University,Xi’an 710018,Shaanxi Province,China [2]Department of Epidemiology,Tianjin Medical University,Tianjin 300070,China [3]Department of Gastroenterology,Clinical School of the Second People's Hospital,Tianjin 300110,China [4]Department of Gastroenterology,The Second Hospital of Tianjin Medical University,Tianjin 300211,China [5]Department of Pathology,Clinical School of the Second People's Hospital,Tianjin 300110,China [6]Department of Gastro-Enterologie,Xining Second People's Hospital,Xining 810003,Qinghai Province,China

出　　处：《World Journal of Hepatology》2024年第12期1407-1416,共10页世界肝病学杂志（英文）

摘　　要：BACKGROUND Autoimmune phenomena can be used in some patients with nonalcoholic fatty liver disease(NAFLD)in the clinic,but these patients are not autoimmune hepatitis patients.AIM To determine whether autoimmunity is present in patients with NAFLD,this study was performed.METHODS A total of 104 patients with NAFLD diagnosed by liver biopsy at Tianjin Second People’s Hospital between 2019 and 2023 were enrolled.The patients were divided into three groups according to their biopsy results:The NAFL(n=36),nonalcoholic steatohepatitis(n=51),and liver cirrhosis groups(n=17).RESULTS The differences in IgA,an immune marker,among the three groups of patients were statistically significant(P=0.025).In all NAFLD patients,antinuclear antibody and anti-smooth muscle antibody were the most common autoantibodies.The antinuclear antibody detection rate was the highest at 48.1%.The cirrhosis group had the highest autoantibody positivity rate(64.7%).Portal enlargement is also common in NAFLD patients.The rates of positivity for portal lymphoplasmacytic infiltration,small bile duct hyperplasia and interfacial hepatitis were highest in the cirrhosis group;the differences between the cirrhosis group and the other two groups were significant(P<0.05).Hepatocellular rosettes were identified only in the cirrhosis group(11.8%).CONCLUSION Autoimmune phenomena occur in NAFLD patients,especially in patients with NAFLD-related cirrhosis,in whom this phenomenon may be more pronounced.

关 键 词：Nonalcoholic fatty liver disease Liver pathology AUTOANTIBODY AUTOIMMUNITY Clinical indicator 

分 类 号：R657.3[医药卫生—外科学]