Different medications for seasonal allergic rhinitis in adults:A systematic review and meta-analysis  

作　　者：Jiang-Yuan Qin Geng Huang Zhi-Hui Pan Lan-Fang Liao Heng-Fen Hu 

机构地区：[1]The Third Department of Surgery,Guangxi Armed Police Corps Hospital,Nanning 530021,Guangxi Zhuang Autonomous Region,China [2]Department of Health,Guangxi Armed Police Corps,Nanning 530021,Guangxi Zhuang Autonomous Region,China [3]Medical School,Hunan Vocational and Technical College of Environmental Biology,Hengyang 421005,Hunan Province,China

出　　处：《World Journal of Meta-Analysis》2024年第4期32-42,共11页世界荟萃分析杂志（英文）

摘　　要：BACKGROUND While the efficacy of medications such as fluticasone furoate(FF),fluticasone propionate(FP),and azelastine-fluticasone(AF)has been substantiated in comparison to their respective placebo controls,uncertainties persist regarding the comparative effectiveness of different intranasal agents.AIM To evaluate the efficacy of FP,FF,and AF in the treatment of adult patients with seasonal allergic rhinitis(SAR)using a meta-analytic approach.METHODS A computer search was conducted in Cochrane Library,PubMed,and EMBASE databases to identify randomized controlled trials assessing the effectiveness and safety of FF,FP,and AF in treating SAR.Data on treatment safety and efficacy were extracted and analyzed through meta-analysis.RESULTS A total of 20 studies were included,comprising 10590 participants.The results of the direct meta-analysis indicated that,compared to placebo,both relative Total Nasal Symptom Score(rTNSS)and relative Total Ocular Symptom Score(rTOSS)significantly decreased post-intervention[mean difference(MD)=-1.48,95%confidence interval(CI):-1.73 to-1.22;MD=-0.66,95%CI:-0.82 to-0.49],with similar findings observed across the FF,FP,and AF subgroups.The network meta-analysis results showed that for improving rTNSS and rTOSS,the SUCRA values ranking from highest to lowest were AF,FP,FF,and placebo.Improvements in rTNSS and rTOSS with FP,FF,and AF were all significantly greater than those observed with placebo,with AF demonstrating superior efficacy compared to both FP and FF.No statistically significant difference in rTNSS improvement was found between FP and FF,although FP exhibited significantly greater improvement in rTOSS compared to FF.CONCLUSION In adult patients with SAR,the combination of azelastine and fluticasone shows a significant effect in improving nasal and ocular symptoms,with FP demonstrating marked improvement in ocular symptoms compared to FF.

关 键 词：Seasonal allergic rhinitis Fluticasone propionate Fluticasone furoate Azelastine-fluticasone 

分 类 号：R711.71[医药卫生—妇产科学]