Role of nitric oxide in cerebral ischemia/reperfusion injury:A biomolecular overview  

作　　者：Roberto Anaya-Prado Abraham I Canseco-Villegas Roberto Anaya-Fernández Michelle Marie Anaya-Fernandez Miguel A Guerrero-Palomera Citlalli Guerrero-Palomera Ivan F Garcia-Ramirez Daniel Gonzalez-Martinez Consuelo Cecilia Azcona-Ramírez Claudia Garcia-Perez Airim L Lizarraga-Valencia Aranza Hernandez-Zepeda Jacqueline F Palomares-Covarrubias Jorge HA Blackaller-Medina Jacqueline Soto-Hintze Mayra C Velarde-Castillo Dayri A Cruz-Melendrez 

机构地区：[1]Department of Research&Department of Surgery,School of Medicine and Health Sciences,Tecnologico de Monterrey,Corporate Hospitals Puerta de Hierro,Zapopan 45116,Jalisco,Mexico [2]Direction of Research and Education,Corporate Hospitals Puerta de Hierro,Zapopan 45116,Jalisco,Mexico [3]Department of Research,School of Medicine and Health Sciences,Tecnologico de Monterrey,Zapopan 45116,Jalisco,Mexico [4]Division of Research and Education,Corporate Hospitals Puerta de Hierro,Zapopan 45116,Jalisco,Mexico [5]Division of Research,School of Medicine,University of Guadalajara,Guadalajara 44340,Jalisco,Mexico [6]Division of Research,School of Medicine,Autonomous University of Guadalajara,Zapopan 45116,Jalisco,Mexico [7]Research&Education,Corporate Hospitals Puerta de Hierro,Zapopan 45116,Jalisco,Mexico [8]Division of Research,Corporate Hospitals Puerta de Hierro,Zapopan 45116,Jalisco,Mexico [9]Research,School of Medicine,UNIVA University,Zapopan 45116,Jalisco,Mexico

出　　处：《World Journal of Clinical Cases》2025年第10期9-13,共5页世界临床病例杂志（英文）

摘　　要：Nitric oxide(NO)is a gaseous molecule produced by 3 different NO synthase(NOS)isoforms:Neural/brain NOS(nNOS/bNOS,type 1),endothelial NOS(eNOS,type 3)and inducible NOS(type 2).Type 1 and 3 NOS are constitutively expressed.NO can serve different purposes:As a vasoactive molecule,as a neurotransmitter or as an immunomodulator.It plays a key role in cerebral ischemia/reperfusion injury(CIRI).Hypoxic episodes simulate the production of oxygen free radicals,leading to mitochondrial and phospholipid damage.Upon reperfusion,increased levels of oxygen trigger oxide synthases;whose products are associated with neuronal damage by promoting lipid peroxidation,nitrosylation and excitotoxicity.Molecular pathways in CIRI can be altered by NOS.Neuroprotective effects are observed with eNOS activity.While nNOS interplay is prone to endothelial inflammation,oxidative stress and apoptosis.Therefore,nNOS appears to be detrimental.The interaction between NO and other free radicals develops peroxynitrite;which is a cytotoxic agent.It plays a main role in the likelihood of hemorrhagic events by tissue plasminogen activator(t-PA).Peroxynitrite scavengers are currently being studied as potential targets to prevent hemorrhagic transformation in CIRI.

关 键 词：Nitric oxide Cerebral ischemia/reperfusion injury Nitric oxide synthase Reactive nitrogen species NITROSYLATION 

分 类 号：R614[医药卫生—麻醉学]