Expression rates of p16,p53 in head and neck cutaneous squamous cell carcinoma based on human-papillomavirus positivity  

作　　者：Ha-Jong Nam Heongrae Ryu Da-Woon Lee Je Yeon Byeon Jun Hyuk Kim Ji Hye Lee Soomin Lim Hwan Jun Choi 

机构地区：[1]Department of Plastic and Reconstructive Surgery,Soonchunhyang University Gumi Hospital,Gumi-si 39371,South Korea [2]Department of Plastic and Reconstructive Surgery,College of Medicine,Soonchunhyang University,Cheonan-si 31151,South Korea [3]Department of Pathology,Soonchunhyang University Hospital,Cheonan-si 31151,South Korea [4]Bachelor of Medicine and Bachelor of Surgery,University College London,Medical School,London WC1E 6DE,United Kingdom

出　　处：《World Journal of Clinical Cases》2025年第9期13-23,共11页世界临床病例杂志（英文）

基　　金：Supported by the National Research Foundation of Korea,No.2020R1A2C1100891;Soonchunhyang University Research Fund,No.2024-05-014.

摘　　要：BACKGROUND The high prevalence of human papillomavirus(HPV)infection in oropharyngeal squamous cell carcinoma(SCC)is well established,and p16 expression is a strong predictor.HPV-related tumors exhibit unique mechanisms that target p16 and p53 proteins.However,research on HPV prevalence and the combined predictive value of p16 and p53 expression in head and neck cutaneous SCC(HNCSCC),particularly in Asian populations,remains limited.This retrospective study surveyed 62 patients with HNSCC(2011-2020),excluding those with facial warts or other skin cancer.AIM To explore the prevalence of HPV and the predictive value of p16 and p53 expression in HNCSCC in Asian populations.METHODS All patients underwent wide excision and biopsy.Immunohistochemical staining for HPV,p16,and p53 yielded positive and negative results.The relevance of each marker was investigated by categorizing the tumor locations into high-risk and middle-risk zones based on recurrence frequency.RESULTS Of the 62 patients,20(32.26%)were male,with an average age of 82.27 years(range 26-103 years).High-risk included 19 cases(30.65%),with the eyelid and lip being the most common sites(five cases,8.06%).Middle-risk included 43 cases(69.35%),with the cheek being the most common(29 cases,46.77%).The p16 expression was detected in 24 patients(38.71%),p53 expression in 42 patients(72.58%),and HPV in five patients(8.06%).No significant association was found between p16 expression and the presence of HPV(P>0.99),with a positive predictive value of 8.33%.CONCLUSION This study revealed that p16,a surrogate HPV marker in oropharyngeal SCC,is not reliable in HNCSCC,providing valuable insights for further research in Asian populations.

关 键 词：Squamous cell carcinoma OROPHARYNGEAL Non-oropharyngeal Human papillomavirus The p16 The p53 

分 类 号：R687.3[医药卫生—骨科学]