Effect of dietary fibre on the gastrointestinal microbiota during critical illness:A scoping review  

作　　者：Angajendra N Ghosh Calum J Walsh Matthew J Maiden Tim P Stinear Adam M Deane 

机构地区：[1]Department of Intensive Care,The Northern Hospital,Epping 3076,Victoria,Australia [2]Department of Microbiology and Immunology,The Peter Doherty Institute for Infection and Immunity,Melbourne 3052,Victoria,Australia [3]Department of Intensive Care,The Royal Melbourne Hospital,The University of Melbourne,Parkville 3050,Victoria,Australia [4]Department of Intensive Care Medicine,The Royal Melbourne Hospital,Parkville 3050,Victoria,Australia

出　　处：《World Journal of Critical Care Medicine》2025年第1期49-59,共11页世界重症医学杂志（英文）

摘　　要：The systemic effects of gastrointestinal(GI)microbiota in health and during chronic diseases is increasingly recognised.Dietary strategies to modulate the GI microbiota during chronic diseases have demonstrated promise.While changes in dietary intake can rapidly change the GI microbiota,the impact of dietary changes during acute critical illness on the microbiota remain uncertain.Dietary fibre is metabolised by carbohydrate-active enzymes and,in health,can alter GI microbiota.The aim of this scoping review was to describe the effects of dietary fibre supplementation in health and disease states,specifically during critical illness.Randomised controlled trials and prospective cohort studies that include adults(>18 years age)and reported changes to GI microbiota as one of the study outcomes using non-culture methods,were identified.Studies show dietary fibres have an impact on faecal microbiota in health and disease.The fibre,inulin,has a marked and specific effect on increasing the abundance of faecal Bifidobacteria.Short chain fatty acids produced by Bifidobacteria have been shown to be beneficial in other patient populations.Very few trials have evaluated the effect of dietary fibre on the GI microbiota during critical illness.More research is necessary to establish optimal fibre type,doses,duration of intervention in critical illness.

关 键 词：Gastrointestinal microbiota Dietary fibre HEALTH Critical illness Short chain fatty acids 

分 类 号：R459.7[医药卫生—急诊医学]