Effect of cholesterol metabolism on hepatolithiasis  

作　　者：Lin Zheng Zi-Yu Ye Jun-Ji Ma 

机构地区：[1]Department of Gastroenterology,The Second Hospital of Hebei Medical University,Hebei Key Laboratory of Gastroenterology,Hebei Institute of Gastroenterology,Hebei Clinical Research Center for Digestive Diseases,No.215 Heping West Road,Shijiazhuang 050000,Hebei Province,China

出　　处：《World Journal of Gastroenterology》2025年第1期157-162,共6页世界胃肠病学杂志（英文）

基　　金：Supported by Hebei Natural Science Foundation,No.H2022206539;Hebei Provincial Government Funded Clinical Talents Training Project,No.ZF2023143.

摘　　要：Surgical intervention is currently the primary treatment for hepatolithiasis;how-ever,some patients still experience residual stones and high recurrence rates after surgery.Cholesterol metabolism seems to play an important role in hepatoli-thiasis pathogenesis.A high cholesterol diet is one of the significant reasons for the increasing incidence of hepatolithiasis.Therefore,regular diet and appropriate medical intervention are crucial measures to prevent hepatolithiasis and reduce recurrence rate after surgery.Reducing dietary cholesterol and drugs that increase cholesterol stone solubility are key therapeutic approaches in treating hepato-lithiasis.This article discusses the cholesterol metabolic pathways related to the pathogenesis of hepatolithiasis,as well as food intake and targeted therapeutic drugs.

关 键 词：HEPATOLITHIASIS Cholesterol metabolism High-fat diet 3-hydroxy-3-methylglutaryl-coenzyme A reductase Interlobular bile duct 

分 类 号：R512.63[医药卫生—内科学] R589[医药卫生—临床医学]