Prevalence of transfusion transmissible infections among various donor groups:A comparative analysis  

作　　者：Sanjay K Thakur Anil K Sinha Santosh K Sharma Aarzoo Jahan Dinesh K Negi Ruchika Gupta Sompal Singh 

机构地区：[1]Regional Blood Transfusion Centre,Hindu Rao Hospital and NDMC Medical College,North Delhi 110007,Delhi,India [2]Department of Zoology,Veer Kunwar Singh University,Ara 802301,Bihar,India [3]Regional Blood Transfusion Centre and Pathology,Hindu Rao Hospital and NDMC Medical College,North Delhi 110007,Delhi,India [4]Department of Cytopathology,ICMR-National Institute of Cancer Prevention and Research,Noida 201301,Uttar Pradesh,India

出　　处：《World Journal of Virology》2025年第1期108-117,共10页世界病毒学杂志（英文）

摘　　要：BACKGROUND Transfusion transmissible infections(TTIs)are illnesses spread through contaminated blood or blood products.In India,screening for TTIs such as hepatitis B virus(HBV),hepatitis C virus(HCV),human immunodeficiency virus(HIV)-I/II,malaria,and syphilis is mandatory before blood transfusions.Worldwide,HCV,HBV,and HIV are the leading viruses causing mortality,affecting millions of people globally,including those with co-infections of HIV/HCV and HIV/HBV.Studies highlight the impact of TTIs on life expectancy and health risks,such as liver cirrhosis,cancer,and other diseases in individuals with chronic HBV.Globally,millions of blood donations take place annually,emphasizing the importance of maintaining blood safety.AIM To study the prevalence of TTIs,viz.,HBV,HCV,HIV I/II,syphilis,and malaria parasite(MP),among different blood donor groups.METHODS The study assessed the prevalence of TTIs among different blood donor groups in Delhi,India.Groups included total donors,in-house donors,total camp donors,institutional camp donors,and community camp donors.Tests for HIV,HBV,and HCV were done using enzyme-linked immunosorbent assay,while syphilis was tested with rapid plasma reagins and MP rapid card methods.The prevalence of HBV,HCV,HIV,and syphilis,expressed as percentages.Differences in infection rates between the groups were analyzed usingχ²tests and P-values(less than 0.05).RESULTS The study evaluated TTIs among 42158 blood donors in Delhi.The overall cumulative frequency of TTIs in total blood donors was 2.071%,and the frequencies of HBV,HCV,HIV-I/II,venereal disease research laboratory,and MP were 1.048%,0.425%,0.221%,0.377%,and 0.0024%,respectively.In-house donors,representing 37656 donors,had the highest transfusion transmissible infection(TTI)prevalence at 2.167%.Among total camp donors(4502 donors),TTIs were identified in 1.266%of donors,while community camp donors(2439 donors)exhibited a prevalence of 1.558%.Institutional camp donors(2063 donors)had the lowest TTI prevalence at 0.921%.Statistical ana

关 键 词：Blood donors Transfusion transmissible infections Hepatitis B virus Human immunodeficiency virus Hepatitis C virus Malaria parasite SYPHILIS 

分 类 号：R563.1[医药卫生—呼吸系统] R575[医药卫生—内科学]