Septic shock due to cytomegalovirus colitis associated with rituximab use:A case report  

作　　者：Siddharth Patel Jordan Jay Prutha Pathak Mc Anto Antony Mrudula Thiriveedi 

机构地区：[1]Department of Internal Medicine,Decatur Morgan Hospital,Decatur,AL 35601,United States [2]Department of Medicine,Alabama College of Osteopathic Medicine,Dothan,AL 36303,United States [3]Department of Internal Medicine,North Alabama Medical Center,Florence,AL 35630,United States [4]Department of Endocrinology,Diabetes and Metabolism,Medical University of South Carolina/AnMed Campus,Anderson,SC 29621,United States

出　　处：《World Journal of Virology》2025年第1期118-123,共6页世界病毒学杂志（英文）

摘　　要：BACKGROUND Cytomegalovirus(CMV)infections can cause significant morbidity and mortality in immunocompromised individuals.CMV targets dysfunctional lymphocytes.Chronic rituximab(RTX)therapy can cause B-lymphocyte dysfunction,increasing CMV risk.Rarely,CMV infections present with critical illness such as septic shock.CASE SUMMARY A 64-year-old African American woman presented with generalized weakness and non-bloody watery diarrhea of 4-6 weeks duration.She did not have nausea,vomiting or,abdominal pain.She had been on monthly RTX infusions for neuromyelitis optica.She was admitted for septic shock due to pancolitis.Blood investigations suggested pancytopenia and serology detected significantly elevated CMV DNA.Valganciclovir treatment led to disease resolution.CONCLUSION This case illustrates an extremely rare case of CMV colitis associated with RTX use presenting with septic shock.High suspicion for rare opportunistic infections is imperative in individuals with long-term RTX use.

关 键 词：Cytomegalovirus colitis Rituximab use Immunocompromised status Septic shock PANCYTOPENIA Case report 

分 类 号：R563.1[医药卫生—呼吸系统]