The efficacy and safety of ureteroscopic lithotripsy and flexible ureteroscopy with continuous anticoagulant or antiplatelet drugs:A multicenter retrospective real-world study  

作　　者：Zijie Xu Chujiang He Jianwei Cao Jianhong Wu Dawei Wang Jun Da Dongliang Xu Mingyue Tan Xiaofeng Gao Yonghan Peng Jie Chen Rong Chen Pengfei Wu Juntao Jiang Lei Chen Shujie Xia Yi Shao 

机构地区：[1]Department of Urology,Shanghai General Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai,China [2]Department of Urology,Xin Hua Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai,China [3]Shanghai Municipal Hospital Urology Specialist Alliance,Shanghai,China [4]Department of Urology,Huadong Hospital,Fudan University,Shanghai,China [5]Department of Urology,Ruijin Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai,China [6]Department of Urology,Shanghai Ninth People's Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai,China [7]Department of Urology,Shuguang Hospital,Shanghai University of Traditional Chinese Medicine,Shanghai,China [8]Department of Urology,Changhai Hospital,Naval Medical University,Shanghai,China [9]Department of Urology,Shanghai Changzheng Hospital,Naval Medical University,Shanghai,China [10]Department of Urology,Shanghai Sixth People's Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai,China [11]Department of Urology,Shanghai Tenth People's Hospital,Tongji University School of Medicine,Shanghai,China

出　　处：《Current Urology》2024年第4期283-286,共4页当代泌尿学（英文）

基　　金：Shanghai Municipal Hospital Urology Specialist Alliance(grant no.SHDC22021314-A,SHDC22021314-B);Scientific and Technological Innovative Action Plan from Science and Technology Commission of Shanghai Municipality(grant nos.20Y11904600 and 23141902100);Shanghai Pujiang Program(grant no.2020PJD046);Science and Technology Foundation of Songjiang District(grant no.18sjkjgg13).

摘　　要：Objective The objective of this study is to assess the effectiveness and safety of ureteroscopic lithotripsy and flexible ureteroscopy(fURS)for treating patients on anticoagulant(AC)or antiplatelet(AP)medications.Patients and Methods The study included 213 patients with urinary stones who underwent ureteroscopic lithotripsy or fURS between January 2019 and October 2022 at the Shanghai Municipal Hospital Urology Specialist Alliance.Among these patients,15 received AC therapy,193 received AP therapy,and 5 received both AC and AP therapy.Patients were divided into 3 groups based on the real-world management of antithrombotic drugs:the continuation group(n=62),the discontinuation group(n=91),and the discontinuation and bridge heparin group(n=60).Intraoperative and postoperative outcomes were compared among the 3 groups.Results Age,sex,body mass index,stone location,stone size,stone side,and residual fragments were not different among the groups.None of the patients received blood transfusions or had thromboembolic events,emergencies for gross hematuria,significant bleeding-related complications,or unplanned secondary ureteroscopic surgery.The mean duration of hospital stay of the continuation group(3.97 days)was significantly lower than that of the discontinuation group(5.99 days)and the discontinuation and bridge heparin group(5.75 days)(p<0.001).Conclusions Ureteroscopic lithotripsy and fURS can be performed safely and effectively in patients on AC or AP drugs,resulting in reduced duration of hospital stay.

关 键 词：Ureteroscopic lithotripsy Flexible ureteroscopy Anticoagulant drugs Antiplatelet drugs 

分 类 号：R699.4[医药卫生—泌尿科学]