踝下动脉球囊成形术中紫杉醇药涂球囊与普通球囊疗效对比  

A short term result of paclitaxel-coated balloon angioplasty versus common balloon angioplasty for below-the-ankle artery sclerosis obliterans

作　　者：李志娟 李天天 庄百溪[1] 张雪原 王煜杰 张轩 杨淼[1] Li Zhijuan;Li Tiantian;Zhuang Baixi;Zhang Xueyuan;Wang Yujie;Zhang Xuan;Yang Miao(Department of Peripheral Vascular Diseases,Xiyuan Hospital,China Academy of Chinese Medical Sciences,Beijing100091,China)

机构地区：[1]中国中医科学院西苑医院周围血管科,北京100091

出　　处：《中华普通外科杂志》2024年第11期855-860,共6页Chinese Journal of General Surgery

摘　　要：目的比较药涂球囊与普通球囊在下肢动脉硬化闭塞症(ASO)踝下病变中的疗效。方法回顾性分析中国中医科学院西苑医院周围血管科2021年6月至2023年6月收治的115例(118条肢体)Rutherford 4~6级ASO患者的临床及随访资料。结果根据治疗方式不同分为药涂球囊组52条肢体,普通球囊组66条肢体。在6个月的随访期内,药涂球囊组创面有效率为98.1%,普通球囊组为92.4%,差异有统计学意义(P<0.05);药涂球囊组踝肱指数增加值、趾肱指数增加值显著优于普通球囊组,差异有统计学意义(P<0.01)。平均6个月随访期内两组均无重大不良事件发生,药涂球囊组在保肢率(100.0%比98.5%)、靶血管重建率(7.7%比18.2%)上优于普通球囊组,但差异无统计学意义(P>0.05)。结论药涂球囊较普通球囊治疗Rutherford 4~6级踝下病变患者创面愈合率和血管通畅率更高。ObjectiveTo compare the short-term efficacy of drug-coated balloon and common balloon in the treatment of with below-the-ankle arteriosclerosis obliterans(ASO).MethodsThe clinical and follow-up data of 115 patients(118 limbs)with lower extremity ASO of Rutherford 4-6 admitted to the Department of Peripheral Vascular Diseases,Xiyuan Hospital,China Academy of Chinese Medical Sciences from Jun 2021 to Jun 2023 were retrospectively analyzed.ResultsPatients were divided into group of 52 limbs using paclitaxel-coated balloon and group of 66 limbs using common balloon.During the 6-month follow-up period,The total effective rate of wound surface was 98.1%in the drug-coated balloon group and 92.4%in the common balloon group.The difference was statistically significant(P<0.05);the increase of ankle-brachial index(ABI)and toe-brachial index(TBI)in the drug-coated balloon group were significantly better than common balloon group,and the difference was statistically significant(P<0.01).No major adverse events occurred in the two groups during the 6-month follow-up period.Compared with the common balloon group,the drug-coated balloon group had a higher limb salvage rate(100.0%vs.98.5%)and a lower target vessel reconstruction rate(7.7%vs.18.2%),though the difference was not statistically significant(P>0.05).ConclusionCompared with the common balloon,the drug-coated balloon is more effective in the treatment of patients with wound healing rate and vascular patency rate in Rutherford 4-6 grade below-the-ankle artery lesions.

关 键 词：闭塞性动脉硬化 血管成形术 气囊 慢性肢体威胁性缺血 踝下病变 

分 类 号：R654.4[医药卫生—外科学]