白细胞介素17与2型糖尿病患者冠状动脉非钙化斑块负荷的相关性及其对不良心血管事件的预测价值  

Correlation between interleukin-17 and coronary atherosclerotic plaque load in type 2 diabetes mellitus patients and its predictive value for adverse cardiovascular events

作　　者：李鹏[1] 张洁[2] 吕忠英[3] Li Peng;Zhang Jie;Lyu Zhongying(Department of Cardiology,the Fifth Affiliated Hospital of Xinjiang Medical University,Urumqi 830000,China;Department of Endocrinology,the Fifth Affiliated Hospital of Xinjiang Medical University,Urumqi 830000,China;Department of Hypertension,the Fifth Affiliated Hospital of Xinjiang Medical University,Urumqi 830000,China)

机构地区：[1]新疆医科大学第五附属医院心内科,乌鲁木齐830011 [2]新疆医科大学第五附属医院内分泌科,乌鲁木齐830011 [3]新疆医科大学第五附属医院高血压科,乌鲁木齐830011

出　　处：《中国医师进修杂志》2024年第12期1057-1060,共4页Chinese Journal of Postgraduates of Medicine

基　　金：新疆维吾尔自治区科技计划项目(2022D01C325)。

摘　　要：目的探讨白细胞介素17(IL-17)与2型糖尿病患者冠状动脉非钙化斑块负荷的相关性及其对不良心血管事件的预测价值。方法回顾性选择新疆医科大学第五附属医院2022年1—11月收治的150例2型糖尿病患者(观察组)和同期150例体检健康者(健康对照组)为研究对象。比较两组IL-17水平和冠状动脉非钙化斑块负荷情况;采用Pearson检验分析血清IL-17水平与非钙化斑块负荷的相关性;对2型糖尿病患者随访1年,采用受试者工作特征(ROC)曲线分析IL-17水平和冠状动脉非斑块负荷对2型糖尿病患者不良心血管事件的预测价值。结果观察组IL-17、空腹血糖、体质量指数、非钙化斑块体积、非钙化斑块负荷、颈动脉内膜中层厚度高于健康对照组[(60.34±15.94)ng/L比(36.30±14.29)ng/L、(9.38±1.47)mmol/L比(5.98±0.61)mmol/L、(26.85±3.42)kg/m^(2)比(24.84±3.00)kg/m^(2)、(165.20±27.37)mm 3比(107.33±36.72)mm 3、(27.82±4.68)%比(17.98±6.17)%、(1.40±0.16)mm比(1.22±0.16)mm],左室射血分数低于健康对照组[(56.58±7.73)%比(67.07±7.95)%],差异有统计学意义(P<0.05)。Pearson检验结果表明,血清IL-17水平与2型糖尿病患者非钙化斑块体积、非钙化斑块负荷、颈动脉内膜中层厚度呈正相关(r=0.161、0.180和0.178,P<0.05)。ROC曲线分析结果显示,血清IL-17、非钙化斑块负荷、非钙化斑块体积对2型糖尿病患者1年内发生不良心血管事件的预测价值较高,曲线下面积分别为0.735(95%CI 0.637~0.832,P=0.001)、0.766(95%CI 0.636~0.896,P<0.001)、0.774(95%CI 0.648~0.901,P<0.001)。结论2型糖尿病患者血清IL-17水平升高,并且血清IL-17水平与冠状动脉非钙化斑块负荷增加有关,对预测不良心血管事件有一定价值。ObjectiveTo investigate the correlation between interleukin-17(IL-17)and non-calcified coronary plaque load in patients with type 2 diabetes mellitus.MethodsFrom January 2022 to November 2022,150 patients with type 2 diabetes mellitus in the Fifth Affiliated Hospital of Xinjiang Medical University were retrospectively collected as the observation group,and 150 healthy adults were collected as the healthy control group at the same time.The levels of IL-17 and coronary non-calcified plaque load between the two groups were compared.The correlation between serum IL-17 level and non-calcified plaque load was analyzed by Pearson test.The patients with type 2 diabetes mellitus were followed up for 1 year,the predictive value of IL-17 and coronary non-plaque load on adverse cardiovascular events in type 2 diabetes patients were analyzed by receiver operating characteristic(ROC)curve.ResultsThe levels of IL-17,fasting blood glucose,body mass index,non-calcified plaque volume,non-calcified plaque load and carotid intima-media thickness in the observation group were higher than those in thehealthy control group:(60.34±15.94)ng/L vs.(36.30±14.29)ng/L,(9.38±1.47)mmol/L vs.(5.98±0.61)mmol/L,(26.85±3.42)kg/m^(2)vs.(24.84±3.00)kg/m^(2),(165.20±27.37)mm 3 vs.(107.33±36.72)mm 3,(27.82±4.68)%vs.(17.98±6.17)%,(1.40±0.16)mm vs.(1.22±0.16)mm;the left ventricular ejection fraction was lower than that in the normal control group:(56.58±7.73)%vs.(67.07±7.95)%,there were statistical differences(P<0.05).The results of Pearson test showed that the level of IL-17 were significantly positively correlated with non-calcified plaque volume,non-calcified plaque load and carotid intima-media thickness in type 2 diabetes mellitus patients(r=0.161,0.180 and 0.178,P<0.05).The results of ROC curve analysis showed that the level of IL-17,non-calcified plaque load,and non-calcified plaque volume had high predictive value for adverse cardiovascular events in type 2 diabetes mellitus patients within 1 year,the area under the curve were 0.735

关 键 词：糖尿病 2型 白细胞介素17 冠状动脉狭窄 非钙化斑块 

分 类 号：R587.1[医药卫生—内分泌] R543.3[医药卫生—内科学]