锌指蛋白A20及碱性成纤维细胞生长因子与慢性乙型肝炎患者肝脏纤维化的相关性研究  

Correlation between zinc finger protein A20 and basic fibroblast growth factor and liver fibrosis inpatientswithchronichepatitis B

作　　者：张松 黄肖雨 孟明辉[1] 胡倩 赵子龙[1] 李健[1] 康海燕[1] 孙殿兴 郭争荣[3] Zhang Song;Huang Xiaoyu;Meng Minghui;Hu Qian;Zhao Zilong;Li Jian;Kang Haiyan;Sun Dianxing;Guo Zhengrong(Department of the Sixth Infection,the Fifth Hospital of Shijiazhuang City,Shjiazhuang 050021,China;Department of Hepatology,the PLA Hepatology Diagnosis and Treatment Center,the 98Oth Hospital of the PLA Joint Service Support Force,Shijiazhuang 050081,China;Department of Gastroenterology,Shijiazhuang People's Hospital,Shijiazhuang 050012,China)

机构地区：[1]石家庄市第五医院感染六科,石家庄050021 [2]中国人民解放军联勤保障部队第九八〇医院肝病科全军肝病诊疗中心,石家庄050081 [3]石家庄市人民医院消化科,石家庄050012

出　　处：《中国医师进修杂志》2024年第12期1061-1064,共4页Chinese Journal of Postgraduates of Medicine

基　　金：河北省2022年度医学科学研究课题计划(20221685)。

摘　　要：目的探讨锌指蛋白A20(A20)及碱性成纤维细胞生长因子(BFGF)与慢性乙型肝炎患者肝脏纤维化的相关性。方法采用回顾性研究的方法,选取2019年1月至2020年12月在石家庄市第五医院诊治的120例慢性乙型肝炎患者,均行肝组织穿刺活检术,另选择行肝脏血管瘤切除术的肝脏病理标本25例,分析肝组织A20、BFGF表达与肝脏病理纤维化分期及炎性反应分级的相关性。结果A20在S1~S4期的表达分别为(7.01±1.98)%、(11.26±3.59)%、(17.68±6.32)%、(27.32±8.73)%,明显高于S0期的(0.93±0.81)%;BFGF在S1~S4期的表达分别为(6.12±1.22)%、(10.18±2.43)%、(16.94±5.06)%、(25.99±7.57)%,明显高于S0期的(0.81±0.29)%,差异均有统计学意义(P<0.05)。A20在G1~G4级的表达分别为(6.56±1.87)%、(10.01±3.29)%、(15.54±5.01)%、(25.86±8.02)%,明显高于G0级的(0.85±0.71)%;BFGF在G1~G4级的表达分别为(5.91±1.52)%、(9.65±2.48)%、(15.03±4.86)%、(24.62±7.22)%,明显高于G0级的(0.79±0.41)%,差异均有统计学意义(P<0.05)。Pearson检验结果表明,肝组织A20表达与BFGF表达呈正相关(r=0.824,P<0.05)。结论肝组织A20、BFGF表达随肝脏病理纤维化分期及炎性反应分级程度加重而增加,可作为评价肝脏纤维化严重程度的重要指标。ObjectiveTo study the correlation between zinc finger protein A20(A20)and basic fibroblast growth factor(BFGF)and liver fibrosis in chronic hepatitis B.MethodsA retrospective study was conducted to select 120 patients with chronic hepatitis B diagnosed and treated in the Fifth Hospital of Shijiazhuang City from January 2019 to December 2020,all of whom underwent liver tissue biopsy,and 25 cases of liver pathological specimens who underwent liver hemangioma resection were selected.The correlation between the expression of A20 and BFGF in liver tissue and the stage of hepatic fibrosis and inflammation were analyzed.ResultsThe expression of A20 in the S1-S4 phase was higher than that in the S0 phase:(6.12±1.22)%,(10.18±2.43)%,(16.94±5.06)%,(25.99±7.57)%vs.(0.81±0.29)%;the expression of BFGF in the S1-S4 phase was higher than that in the S0 phase:(6.12±1.22)%,(10.18±2.43)%,(16.94±5.06)%,(25.99±7.57)%vs.(0.81±0.29)%,there were statistical differences(P<0.05).The expression of A20 in the G1-G4 phase was higher than that in the G0 phase:(6.56±1.87)%,(10.01±3.29)%,(15.54±5.01)%,(25.86±8.02)%vs.(0.85±0.71)%;the expression of BFGF in the G1-G4 phase was higher than that in the G0 phase:(5.91±1.52)%,(9.65±2.48)%,(15.03±4.86)%,(24.62±7.22)%vs.(0.79±0.41)%,there were statistical differences(P<0.05).The results of Pearson test showed that there was a positive correlation between liver A20 and BFGF(r=0.824,P<0.05).ConclusionsThe expressions of A20 and BFGF in liver tissue increase with the aggravation of liver pathological fibrosis and inflammation,which can be used as important indicators to evaluate the severity of liver fibrosis.

关 键 词：肝炎 乙型 慢性 纤维化 锌指蛋白A20 碱性成纤维细胞生长因子 

分 类 号：R512.62[医药卫生—内科学] R575.2[医药卫生—临床医学]