氨甲环酸在肘关节松解术中的应用进展  

Advances in the application of tranexamic acid in elbow arthrolysis

作　　者：张建宇 陈辰 蒋协远 Zhang Jianyu;Chen Chen;Jiang Xieyuan(Department of Orthopedic Trauma,Beijing Jishuitan Hospital,Capital Medical University,Beijing 100035,China)

机构地区：[1]首都医科大学附属北京积水潭医院创伤骨科,北京100035

出　　处：《国际外科学杂志》2024年第11期721-724,共4页International Journal of Surgery

基　　金：北京市科学技术协会青年人才托举工程(BYESS2023115);北京市卫生健康科技成果和适宜技术推广项目(BHTPP2022012);北京积水潭医院青年人才培养"学科新星"计划(XKXX202103)。

摘　　要：肘关节僵硬常导致肘关节活动范围受限,对患者日常活动会造成较大影响。肘关节松解术是治疗肘关节僵硬的常用方法。目前该手术存在术中及术后出血量多、引流量大的问题。氨甲环酸作为一种抗纤溶药物,在开放性及关节镜下肘关节松解术中得到了较为广泛地应用,其应用方式主要包括局部应用、静脉滴注以及局部与静脉联合应用。氨甲环酸可以有效减少肘关节松解术后出血量或引流量,且不增加血栓相关并发症风险,有助于患者早期恢复,提高患者的术后满意度。未来研究应关注氨甲环酸的不同用药方式和剂量对其疗效的影响,以期优化治疗方案。氨甲环酸在肘关节松解术中的应用前景良好,进一步的大规模研究将有助于其广泛应用。Elbow stiffness leads to a restricted range of motion,significantly impacting daily activities of patients.Elbow arthrolysis is a commonly used procedure for treating elbow stiffness.However,the procedure is associated with substantial intraoperative and postoperative bleeding,as well as high drainage volume.As an antifibrinolytic agent,tranexamic acid has been increasingly applied in both open and arthroscopic elbow arthrolysis,and its application methods include topical application,intravenous infusion,and combined topical-intravenous application.Studies indicated that tranexamic acid can effectively reduce postoperative bleeding and drainage without increasing the risk of thromboembolic complications,thereby facilitating early recovery and enhancing postoperative patient satisfaction.Future research should focus on optimizing treatment protocols by evaluating the efficacy of different administration methods and dosages of tranexamic acid.The application of tranexamic acid in elbow arthrolysis shows promising potential,and further large-scale studies will be instrumental in supporting its widespread use.

关 键 词：氨甲环酸 肘关节 失血 手术 肘关节松解术 

分 类 号：R687.4[医药卫生—骨科学]